Bruno O - Search Results

1

Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry.

Brullo C, Rapetti F, Bruno O. Brullo C, et al. Among authors: bruno o. Molecules. 2020 Jul 29;25(15):3457. doi: 10.3390/molecules25153457. Molecules. 2020. PMID: 32751358 Free PMC article. Review.

2

New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets.

Brullo C, Massa M, Rapetti F, Alfei S, Bertolotto MB, Montecucco F, Signorello MG, Bruno O. Brullo C, et al. Among authors: bruno o. Molecules. 2020 Feb 18;25(4):899. doi: 10.3390/molecules25040899. Molecules. 2020. PMID: 32085423 Free PMC article.

3

Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems.

Brullo C, Rapetti F, Alfei S, Maric I, Rizzelli F, Mapelli M, Rosano C, Viale M, Bruno O. Brullo C, et al. Among authors: bruno o. ChemMedChem. 2020 Jun 4;15(11):961-969. doi: 10.1002/cmdc.202000122. Epub 2020 Apr 27. ChemMedChem. 2020. PMID: 32233110

4

Synthesis, functional proteomics and biological evaluation of new 5-pyrazolyl ureas as potential anti-angiogenic compounds.

Morretta E, Sidibè A, Spallarossa A, Petrella A, Meta E, Bruno O, Monti MC, Brullo C. Morretta E, et al. Among authors: bruno o. Eur J Med Chem. 2021 Dec 15;226:113872. doi: 10.1016/j.ejmech.2021.113872. Epub 2021 Sep 25. Eur J Med Chem. 2021. PMID: 34600191

5

New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways.

Signorello MG, Rapetti F, Meta E, Sidibè A, Bruno O, Brullo C. Signorello MG, et al. Among authors: bruno o. Molecules. 2021 Sep 22;26(19):5735. doi: 10.3390/molecules26195735. Molecules. 2021. PMID: 34641279 Free PMC article.

6

Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis.

Bruno O, Brullo C, Bondavalli F, Schenone S, Ranise A, Arduino N, Bertolotto MB, Montecucco F, Ottonello L, Dallegri F, Tognolini M, Ballabeni V, Bertoni S, Barocelli E. Bruno O, et al. J Med Chem. 2007 Jul 26;50(15):3618-26. doi: 10.1021/jm0704402. Epub 2007 Jul 4. J Med Chem. 2007. PMID: 17608466

7

Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines.

Schenone S, Brullo C, Bruno O, Bondavalli F, Mosti L, Maga G, Crespan E, Carraro F, Manetti F, Tintori C, Botta M. Schenone S, et al. Among authors: bruno o. Eur J Med Chem. 2008 Dec;43(12):2665-76. doi: 10.1016/j.ejmech.2008.01.034. Epub 2008 Feb 6. Eur J Med Chem. 2008. PMID: 18342402

8

New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms.

Bruno O, Romussi A, Spallarossa A, Brullo C, Schenone S, Bondavalli F, Vanthuyne N, Roussel C. Bruno O, et al. J Med Chem. 2009 Nov 12;52(21):6546-57. doi: 10.1021/jm900977c. J Med Chem. 2009. PMID: 19827751

9

N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis.

Brullo C, Spisani S, Selvatici R, Bruno O. Brullo C, et al. Among authors: bruno o. Eur J Med Chem. 2012 Jan;47(1):573-9. doi: 10.1016/j.ejmech.2011.11.031. Epub 2011 Nov 25. Eur J Med Chem. 2012. PMID: 22152986

10

Synthesis, biological evaluation, and molecular modeling of new 3-(cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) related phosphodiesterase 4D (PDE4D) inhibitors.

Brullo C, Massa M, Rocca M, Rotolo C, Guariento S, Rivera D, Ricciarelli R, Fedele E, Fossa P, Bruno O. Brullo C, et al. Among authors: bruno o. J Med Chem. 2014 Aug 28;57(16):7061-72. doi: 10.1021/jm500855w. Epub 2014 Aug 15. J Med Chem. 2014. PMID: 25126889

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