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Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat Biotechnol. 2022 May;40(5):769-778. doi: 10.1038/s41587-021-01126-9. Epub 2022 Jan 6.
Nat Biotechnol. 2022.
PMID: 34992247
Unlocking latent kinetic information from label-free binding.
Quinn JG, Steffek M, Bruning JM, Frommlet A, Mulvihill MM.
Quinn JG, et al. Among authors: bruning jm.
Sci Rep. 2019 Dec 5;9(1):18389. doi: 10.1038/s41598-019-54485-4.
Sci Rep. 2019.
PMID: 31804511
Free PMC article.
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A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Steffek M, Helgason E, Popovych N, Rougé L, Bruning JM, Li KS, Burdick DJ, Cai J, Crawford T, Xue J, Decurtins W, Fang C, Grubers F, Holliday MJ, Langley A, Petersen A, Satz AL, Song A, Stoffler D, Strebel Q, Tom JYK, Skelton N, Staben ST, Wichert M, Mulvihill MM, Dueber EC.
Steffek M, et al. Among authors: bruning jm.
Biochemistry. 2023 Feb 7;62(3):633-644. doi: 10.1021/acs.biochem.1c00682. Epub 2022 Jan 5.
Biochemistry. 2023.
PMID: 34985287
Free article.
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Structural basis for SHOC2 modulation of RAS signalling.
Liau NPD, Johnson MC, Izadi S, Gerosa L, Hammel M, Bruning JM, Wendorff TJ, Phung W, Hymowitz SG, Sudhamsu J.
Liau NPD, et al. Among authors: bruning jm.
Nature. 2022 Sep;609(7926):400-407. doi: 10.1038/s41586-022-04838-3. Epub 2022 Jun 29.
Nature. 2022.
PMID: 35768504
Free PMC article.
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Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2).
de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM.
de Jesus Cortez F, et al. Among authors: bruning jm.
PLoS One. 2016 Jul 28;11(7):e0159316. doi: 10.1371/journal.pone.0159316. eCollection 2016.
PLoS One. 2016.
PMID: 27467220
Free PMC article.
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Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite.
Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM.
Bruning JM, et al.
Cell Chem Biol. 2019 May 16;26(5):674-685.e6. doi: 10.1016/j.chembiol.2019.02.002. Epub 2019 Mar 7.
Cell Chem Biol. 2019.
PMID: 30853418
Free PMC article.
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