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Mutant NPM1 Maintains the Leukemic State through HOX Expression.
Brunetti L, Gundry MC, Sorcini D, Guzman AG, Huang YH, Ramabadran R, Gionfriddo I, Mezzasoma F, Milano F, Nabet B, Buckley DL, Kornblau SM, Lin CY, Sportoletti P, Martelli MP, Falini B, Goodell MA. Brunetti L, et al. Cancer Cell. 2018 Sep 10;34(3):499-512.e9. doi: 10.1016/j.ccell.2018.08.005. Cancer Cell. 2018. PMID: 30205049 Free PMC article.
CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice.
Martelli MP, Pettirossi V, Thiede C, Bonifacio E, Mezzasoma F, Cecchini D, Pacini R, Tabarrini A, Ciurnelli R, Gionfriddo I, Manes N, Rossi R, Giunchi L, Oelschlägel U, Brunetti L, Gemei M, Delia M, Specchia G, Liso A, Di Ianni M, Di Raimondo F, Falzetti F, Del Vecchio L, Martelli MF, Falini B. Martelli MP, et al. Among authors: brunetti l. Blood. 2010 Nov 11;116(19):3907-22. doi: 10.1182/blood-2009-08-238899. Epub 2010 Jul 15. Blood. 2010. PMID: 20634376 Free article.
Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.
Martelli MP, Gionfriddo I, Mezzasoma F, Milano F, Pierangeli S, Mulas F, Pacini R, Tabarrini A, Pettirossi V, Rossi R, Vetro C, Brunetti L, Sportoletti P, Tiacci E, Di Raimondo F, Falini B. Martelli MP, et al. Among authors: brunetti l. Blood. 2015 May 28;125(22):3455-65. doi: 10.1182/blood-2014-11-611459. Epub 2015 Mar 20. Blood. 2015. PMID: 25795919 Free article.
Dactinomycin in NPM1-Mutated Acute Myeloid Leukemia.
Falini B, Brunetti L, Martelli MP. Falini B, et al. Among authors: brunetti l. N Engl J Med. 2015 Sep 17;373(12):1180-2. doi: 10.1056/NEJMc1509584. N Engl J Med. 2015. PMID: 26376154 No abstract available.
DNMT3A in Leukemia.
Brunetti L, Gundry MC, Goodell MA. Brunetti L, et al. Cold Spring Harb Perspect Med. 2017 Feb 1;7(2):a030320. doi: 10.1101/cshperspect.a030320. Cold Spring Harb Perspect Med. 2017. PMID: 28003281 Free PMC article. Review.
DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A.
Huang YH, Su J, Lei Y, Brunetti L, Gundry MC, Zhang X, Jeong M, Li W, Goodell MA. Huang YH, et al. Among authors: brunetti l. Genome Biol. 2017 Sep 18;18(1):176. doi: 10.1186/s13059-017-1306-z. Genome Biol. 2017. PMID: 28923089 Free PMC article.
430 results