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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrén E. Casarotto PC, et al. Among authors: brunello ca. Cell. 2021 Mar 4;184(5):1299-1313.e19. doi: 10.1016/j.cell.2021.01.034. Epub 2021 Feb 18. Cell. 2021. PMID: 33606976 Free PMC article.
Microtechnologies to fuel neurobiological research with nanometer precision.
Brunello CA, Jokinen V, Sakha P, Terazono H, Nomura F, Kaneko T, Lauri SE, Franssila S, Rivera C, Yasuda K, Huttunen HJ. Brunello CA, et al. J Nanobiotechnology. 2013 Apr 10;11:11. doi: 10.1186/1477-3155-11-11. J Nanobiotechnology. 2013. PMID: 23575365 Free PMC article. Review.
Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2.
Fred SM, Laukkanen L, Brunello CA, Vesa L, Göös H, Cardon I, Moliner R, Maritzen T, Varjosalo M, Casarotto PC, Castrén E. Fred SM, et al. Among authors: brunello ca. J Biol Chem. 2019 Nov 29;294(48):18150-18161. doi: 10.1074/jbc.RA119.008837. Epub 2019 Oct 20. J Biol Chem. 2019. PMID: 31631060 Free PMC article.
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.
Moliner R, Girych M, Brunello CA, Kovaleva V, Biojone C, Enkavi G, Antenucci L, Kot EF, Goncharuk SA, Kaurinkoski K, Kuutti M, Fred SM, Elsilä LV, Sakson S, Cannarozzo C, Diniz CRAF, Seiffert N, Rubiolo A, Haapaniemi H, Meshi E, Nagaeva E, Öhman T, Róg T, Kankuri E, Vilar M, Varjosalo M, Korpi ER, Permi P, Mineev KS, Saarma M, Vattulainen I, Casarotto PC, Castrén E. Moliner R, et al. Among authors: brunello ca. Nat Neurosci. 2023 Jun;26(6):1032-1041. doi: 10.1038/s41593-023-01316-5. Epub 2023 Jun 5. Nat Neurosci. 2023. PMID: 37280397 Free PMC article.
FRMD4A-cytohesin signaling modulates the cellular release of tau.
Yan X, Nykänen NP, Brunello CA, Haapasalo A, Hiltunen M, Uronen RL, Huttunen HJ. Yan X, et al. Among authors: brunello ca. J Cell Sci. 2016 May 15;129(10):2003-15. doi: 10.1242/jcs.180745. Epub 2016 Apr 4. J Cell Sci. 2016. PMID: 27044754
Secretion of Tau via an Unconventional Non-vesicular Mechanism.
Merezhko M, Brunello CA, Yan X, Vihinen H, Jokitalo E, Uronen RL, Huttunen HJ. Merezhko M, et al. Among authors: brunello ca. Cell Rep. 2018 Nov 20;25(8):2027-2035.e4. doi: 10.1016/j.celrep.2018.10.078. Cell Rep. 2018. PMID: 30463001 Free article.
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