Brun R - Search Results

1

2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.

Prati F, Bergamini C, Molina MT, Falchi F, Cavalli A, Kaiser M, Brun R, Fato R, Bolognesi ML. Prati F, et al. Among authors: brun r. J Med Chem. 2015 Aug 27;58(16):6422-34. doi: 10.1021/acs.jmedchem.5b00748. Epub 2015 Aug 11. J Med Chem. 2015. PMID: 26237241

2

DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.

Dardonville C, Barrett MP, Brun R, Kaiser M, Tanious F, Wilson WD. Dardonville C, et al. Among authors: brun r. J Med Chem. 2006 Jun 15;49(12):3748-52. doi: 10.1021/jm060295c. J Med Chem. 2006. PMID: 16759117 Free article.

3

Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.

Bolognesi ML, Lizzi F, Perozzo R, Brun R, Cavalli A. Bolognesi ML, et al. Among authors: brun r. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2272-6. doi: 10.1016/j.bmcl.2008.03.009. Epub 2008 Mar 7. Bioorg Med Chem Lett. 2008. PMID: 18353643

4

Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.

Cavalli A, Lizzi F, Bongarzone S, Brun R, Luise Krauth-Siegel R, Bolognesi ML. Cavalli A, et al. Among authors: brun r. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3031-5. doi: 10.1016/j.bmcl.2009.04.060. Epub 2009 Apr 20. Bioorg Med Chem Lett. 2009. PMID: 19414258

5

Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.

Lizzi F, Veronesi G, Belluti F, Bergamini C, López-Sánchez A, Kaiser M, Brun R, Krauth-Siegel RL, Hall DG, Rivas L, Bolognesi ML. Lizzi F, et al. Among authors: brun r. J Med Chem. 2012 Dec 13;55(23):10490-500. doi: 10.1021/jm301112z. Epub 2012 Nov 28. J Med Chem. 2012. PMID: 23153330

6

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

Pieretti S, Haanstra JR, Mazet M, Perozzo R, Bergamini C, Prati F, Fato R, Lenaz G, Capranico G, Brun R, Bakker BM, Michels PA, Scapozza L, Bolognesi ML, Cavalli A. Pieretti S, et al. Among authors: brun r. PLoS Negl Trop Dis. 2013;7(1):e2012. doi: 10.1371/journal.pntd.0002012. Epub 2013 Jan 17. PLoS Negl Trop Dis. 2013. PMID: 23350008 Free PMC article.

7

Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI).

Belluti F, Perozzo R, Lauciello L, Colizzi F, Kostrewa D, Bisi A, Gobbi S, Rampa A, Bolognesi ML, Recanatini M, Brun R, Scapozza L, Cavalli A. Belluti F, et al. Among authors: brun r. J Med Chem. 2013 Oct 10;56(19):7516-26. doi: 10.1021/jm400637m. Epub 2013 Sep 25. J Med Chem. 2013. PMID: 24063369

8

Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi.

Belluti F, Uliassi E, Veronesi G, Bergamini C, Kaiser M, Brun R, Viola A, Fato R, Michels PA, Krauth-Siegel RL, Cavalli A, Bolognesi ML. Belluti F, et al. Among authors: brun r. ChemMedChem. 2014 Feb;9(2):371-82. doi: 10.1002/cmdc.201300399. Epub 2014 Jan 8. ChemMedChem. 2014. PMID: 24403089

9

Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.

Karaaslan C, Kaiser M, Brun R, Göker H. Karaaslan C, et al. Among authors: brun r. Bioorg Med Chem. 2016 Sep 15;24(18):4038-4044. doi: 10.1016/j.bmc.2016.06.047. Epub 2016 Jun 25. Bioorg Med Chem. 2016. PMID: 27387356

10

Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.

Kuettel S, Zambon A, Kaiser M, Brun R, Scapozza L, Perozzo R. Kuettel S, et al. Among authors: brun r. J Med Chem. 2007 Nov 15;50(23):5833-9. doi: 10.1021/jm700938n. Epub 2007 Oct 20. J Med Chem. 2007. PMID: 17949068

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