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CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1.
Miao B, Hu Z, Mezzadra R, Hoeijmakers L, Fauster A, Du S, Yang Z, Sator-Schmitt M, Engel H, Li X, Broderick C, Jin G, Gomez-Eerland R, Rozeman L, Lei X, Matsuo H, Yang C, Hofland I, Peters D, Broeks A, Laport E, Fitz A, Zhao X, Mahmoud MAA, Ma X, Sander S, Liu HK, Cui G, Gan Y, Wu W, Xiao Y, Heck AJR, Guan W, Lowe SW, Horlings HM, Wang C, Brummelkamp TR, Blank CU, Schumacher TNM, Sun C. Miao B, et al. Among authors: brummelkamp tr. Cancer Cell. 2023 Oct 9;41(10):1817-1828.e9. doi: 10.1016/j.ccell.2023.08.008. Epub 2023 Sep 7. Cancer Cell. 2023. PMID: 37683639 Free article.
Identification of an alternative triglyceride biosynthesis pathway.
McLelland GL, Lopez-Osias M, Verzijl CRC, Ellenbroek BD, Oliveira RA, Boon NJ, Dekker M, van den Hengel LG, Ali R, Janssen H, Song JY, Krimpenfort P, van Zutphen T, Jonker JW, Brummelkamp TR. McLelland GL, et al. Among authors: brummelkamp tr. Nature. 2023 Sep;621(7977):171-178. doi: 10.1038/s41586-023-06497-4. Epub 2023 Aug 30. Nature. 2023. PMID: 37648867 Free PMC article.
FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks.
Mazouzi A, Moser SC, Abascal F, van den Broek B, Del Castillo Velasco-Herrera M, van der Heijden I, Hekkelman M, Drenth AP, van der Burg E, Kroese LJ, Jalink K, Adams DJ, Jonkers J, Brummelkamp TR. Mazouzi A, et al. Among authors: brummelkamp tr. Sci Adv. 2023 Jun 2;9(22):eadf4409. doi: 10.1126/sciadv.adf4409. Epub 2023 May 31. Sci Adv. 2023. PMID: 37256941 Free PMC article.
Actin maturation requires the ACTMAP/C19orf54 protease.
Haahr P, Galli RA, van den Hengel LG, Bleijerveld OB, Kazokaitė-Adomaitienė J, Song JY, Kroese LJ, Krimpenfort P, Baltissen MP, Vermeulen M, Ottenheijm CAC, Brummelkamp TR. Haahr P, et al. Among authors: brummelkamp tr. Science. 2022 Sep 30;377(6614):1533-1537. doi: 10.1126/science.abq5082. Epub 2022 Sep 29. Science. 2022. PMID: 36173861
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.
van Ruiten MS, van Gent D, Sedeño Cacciatore Á, Fauster A, Willems L, Hekkelman ML, Hoekman L, Altelaar M, Haarhuis JHI, Brummelkamp TR, de Wit E, Rowland BD. van Ruiten MS, et al. Among authors: brummelkamp tr. Nat Struct Mol Biol. 2022 Jun;29(6):586-591. doi: 10.1038/s41594-022-00773-z. Epub 2022 Jun 16. Nat Struct Mol Biol. 2022. PMID: 35710836 Free PMC article.
Posttranslational modification of microtubules by the MATCAP detyrosinase.
Landskron L, Bak J, Adamopoulos A, Kaplani K, Moraiti M, van den Hengel LG, Song JY, Bleijerveld OB, Nieuwenhuis J, Heidebrecht T, Henneman L, Moutin MJ, Barisic M, Taraviras S, Perrakis A, Brummelkamp TR. Landskron L, et al. Among authors: brummelkamp tr. Science. 2022 May 20;376(6595):eabn6020. doi: 10.1126/science.abn6020. Epub 2022 May 20. Science. 2022. PMID: 35482892
A Mediator-cohesin axis controls heterochromatin domain formation.
Haarhuis JHI, van der Weide RH, Blomen VA, Flach KD, Teunissen H, Willems L, Brummelkamp TR, Rowland BD, de Wit E. Haarhuis JHI, et al. Among authors: brummelkamp tr. Nat Commun. 2022 Feb 8;13(1):754. doi: 10.1038/s41467-022-28377-7. Nat Commun. 2022. PMID: 35136067 Free PMC article.
The SPPL3-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses.
Jongsma MLM, de Waard AA, Raaben M, Zhang T, Cabukusta B, Platzer R, Blomen VA, Xagara A, Verkerk T, Bliss S, Kong X, Gerke C, Janssen L, Stickel E, Holst S, Plomp R, Mulder A, Ferrone S, Claas FHJ, Heemskerk MHM, Griffioen M, Halenius A, Overkleeft H, Huppa JB, Wuhrer M, Brummelkamp TR, Neefjes J, Spaapen RM. Jongsma MLM, et al. Among authors: brummelkamp tr. Immunity. 2021 Feb 9;54(2):387. doi: 10.1016/j.immuni.2021.01.016. Immunity. 2021. PMID: 33567263 Free article. No abstract available.
96 results