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Bistacrines as potential antitrypanosomal agents.
Schmidt I, Göllner S, Fuß A, Stich A, Kucharski A, Schirmeister T, Katzowitsch E, Bruhn H, Miliu A, Krauth-Siegel RL, Holzgrabe U. Schmidt I, et al. Among authors: bruhn h. Bioorg Med Chem. 2017 Aug 15;25(16):4526-4531. doi: 10.1016/j.bmc.2017.06.051. Epub 2017 Jul 1. Bioorg Med Chem. 2017. PMID: 28698054
Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei.
Seufert F, Kuhn M, Hein M, Weiwad M, Vivoli M, Norville IH, Sarkar-Tyson M, Marshall LE, Schweimer K, Bruhn H, Rösch P, Harmer NJ, Sotriffer CA, Holzgrabe U. Seufert F, et al. Among authors: bruhn h. Bioorg Med Chem. 2016 Nov 1;24(21):5134-5147. doi: 10.1016/j.bmc.2016.08.025. Epub 2016 Aug 20. Bioorg Med Chem. 2016. PMID: 27591009
Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity.
Hiltensperger G, Hecht N, Kaiser M, Rybak JC, Hoerst A, Dannenbauer N, Müller-Buschbaum K, Bruhn H, Esch H, Lehmann L, Meinel L, Holzgrabe U. Hiltensperger G, et al. Among authors: bruhn h. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4442-52. doi: 10.1128/AAC.01757-15. Print 2016 Aug. Antimicrob Agents Chemother. 2016. PMID: 27139467 Free PMC article.
Anti-trypanosomal activities and structural chemical properties of selected compound classes.
Ponte-Sucre A, Bruhn H, Schirmeister T, Cecil A, Albert CR, Buechold C, Tischer M, Schlesinger S, Goebel T, Fuß A, Mathein D, Merget B, Sotriffer CA, Stich A, Krohne G, Engstler M, Bringmann G, Holzgrabe U. Ponte-Sucre A, et al. Among authors: bruhn h. Parasitol Res. 2015 Feb;114(2):501-12. doi: 10.1007/s00436-014-4210-4. Epub 2014 Nov 23. Parasitol Res. 2015. PMID: 25416330
Mapping the pharmaceutical design space by amorphous ionic liquid strategies.
Wiest J, Saedtler M, Balk A, Merget B, Widmer T, Bruhn H, Raccuglia M, Walid E, Picard F, Stopper H, Dekant W, Lühmann T, Sotriffer C, Galli B, Holzgrabe U, Meinel L. Wiest J, et al. Among authors: bruhn h. J Control Release. 2017 Dec 28;268:314-322. doi: 10.1016/j.jconrel.2017.10.040. Epub 2017 Oct 31. J Control Release. 2017. PMID: 29097303
Ionic liquid versus prodrug strategy to address formulation challenges.
Balk A, Widmer T, Wiest J, Bruhn H, Rybak JC, Matthes P, Müller-Buschbaum K, Sakalis A, Lühmann T, Berghausen J, Holzgrabe U, Galli B, Meinel L. Balk A, et al. Among authors: bruhn h. Pharm Res. 2015 Jun;32(6):2154-67. doi: 10.1007/s11095-014-1607-9. Epub 2014 Dec 23. Pharm Res. 2015. PMID: 25534684
Modelling antibiotic and cytotoxic isoquinoline effects in Staphylococcus aureus, Staphylococcus epidermidis and mammalian cells.
Cecil A, Ohlsen K, Menzel T, François P, Schrenzel J, Fischer A, Dörries K, Selle M, Lalk M, Hantzschmann J, Dittrich M, Liang C, Bernhardt J, Ölschläger TA, Bringmann G, Bruhn H, Unger M, Ponte-Sucre A, Lehmann L, Dandekar T. Cecil A, et al. Among authors: bruhn h. Int J Med Microbiol. 2015 Jan;305(1):96-109. doi: 10.1016/j.ijmm.2014.11.006. Epub 2014 Nov 27. Int J Med Microbiol. 2015. PMID: 25500547
269 results