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Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development.
Oncogene. 2018 Oct;37(42):5694-5700. doi: 10.1038/s41388-018-0357-2. Epub 2018 Jun 15.
Oncogene. 2018.
PMID: 29907769
Free PMC article.
Tumors Widely Express Hundreds of Embryonic Germline Genes.
Bruggeman JW, Irie N, Lodder P, van Pelt AMM, Koster J, Hamer G.
Bruggeman JW, et al.
Cancers (Basel). 2020 Dec 17;12(12):3812. doi: 10.3390/cancers12123812.
Cancers (Basel). 2020.
PMID: 33348709
Free PMC article.
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How germline genes promote malignancy in cancer cells.
Bruggeman JW, Koster J, van Pelt AMM, Speijer D, Hamer G.
Bruggeman JW, et al.
Bioessays. 2023 Jan;45(1):e2200112. doi: 10.1002/bies.202200112. Epub 2022 Oct 27.
Bioessays. 2023.
PMID: 36300921
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Germline specific genes increase DNA double-strand break repair and radioresistance in lung adenocarcinoma cells.
Liu W, Bruggeman JW, Lei Q, van Pelt AMM, Koster J, Hamer G.
Liu W, et al. Among authors: bruggeman jw.
Cell Death Dis. 2024 Jan 12;15(1):38. doi: 10.1038/s41419-024-06433-y.
Cell Death Dis. 2024.
PMID: 38216586
Free PMC article.
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