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Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes.
Lugenbiel P, Govorov K, Syren P, Rahm AK, Wieder T, Wunsch M, Weiberg N, Manolova E, Gramlich D, Rivinius R, Finke D, Lehmann LH, Schweizer PA, Frank D, El Tahry FA, Bruehl C, Heimberger T, Sandke S, Weis T, Most P, Schmack B, Ruhparwar A, Karck M, Frey N, Katus HA, Thomas D. Lugenbiel P, et al. Among authors: bruehl c. Basic Res Cardiol. 2021 Feb 25;116(1):13. doi: 10.1007/s00395-021-00855-x. Basic Res Cardiol. 2021. PMID: 33630168
The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease.
Weigl I, Geschwill P, Reiss M, Bruehl C, Draguhn A, Koenen M, Sedaghat-Hamedani F, Meder B, Thomas D, Katus HA, Schweizer PA. Weigl I, et al. Among authors: bruehl c. Biochem Biophys Res Commun. 2019 Oct 29;519(1):141-147. doi: 10.1016/j.bbrc.2019.08.150. Epub 2019 Aug 31. Biochem Biophys Res Commun. 2019. PMID: 31481236
TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control.
Lugenbiel P, Wenz F, Syren P, Geschwill P, Govorov K, Seyler C, Frank D, Schweizer PA, Franke J, Weis T, Bruehl C, Schmack B, Ruhparwar A, Karck M, Frey N, Katus HA, Thomas D. Lugenbiel P, et al. Among authors: bruehl c. Basic Res Cardiol. 2017 Jan;112(1):8. doi: 10.1007/s00395-016-0597-7. Epub 2016 Dec 22. Basic Res Cardiol. 2017. PMID: 28005193
55 results