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Viral infectivity in pediatric SARS-CoV-2 clinical samples does not vary by age.
Schmidt MM, Despres HW, Shirley DJ, Bose ME, McCaul KC, Crothers JW, Henrickson KJ, Lee B, Bruce EA. Schmidt MM, et al. Among authors: bruce ea. medRxiv [Preprint]. 2022 Oct 18:2022.10.17.22281193. doi: 10.1101/2022.10.17.22281193. medRxiv. 2022. PMID: 36299435 Free PMC article. Updated. Preprint.
NEDD4 family ubiquitin ligases associate with LCMV Z's PPXY domain and are required for virus budding, but not via direct ubiquitination of Z.
Ziegler CM, Dang L, Eisenhauer P, Kelly JA, King BR, Klaus JP, Manuelyan I, Mattice EB, Shirley DJ, Weir ME, Bruce EA, Ballif BA, Botten J. Ziegler CM, et al. Among authors: bruce ea. PLoS Pathog. 2019 Nov 11;15(11):e1008100. doi: 10.1371/journal.ppat.1008100. eCollection 2019 Nov. PLoS Pathog. 2019. PMID: 31710650 Free PMC article.
DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP.
Bruce EA, Huang ML, Perchetti GA, Tighe S, Laaguiby P, Hoffman JJ, Gerrard DL, Nalla AK, Wei Y, Greninger AL, Diehl SA, Shirley DJ, Leonard DGB, Huston CD, Kirkpatrick BD, Dragon JA, Crothers JW, Jerome KR, Botten JW. Bruce EA, et al. bioRxiv [Preprint]. 2020 Apr 6:2020.03.20.001008. doi: 10.1101/2020.03.20.001008. bioRxiv. 2020. PMID: 32511328 Free PMC article. Updated. Preprint.
Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a function of Age and Biological Sex.
Graham NR, Whitaker AN, Strother CA, Miles AK, Grier D, McElvany BD, Bruce EA, Poynter ME, Pierce KK, Kirkpatrick BD, Stapleton RD, An G, Botten JW, Crothers JW, Diehl SA. Graham NR, et al. Among authors: bruce ea. medRxiv [Preprint]. 2020 Jul 16:2020.07.15.20154443. doi: 10.1101/2020.07.15.20154443. medRxiv. 2020. PMID: 32743592 Free PMC article. Updated. Preprint.
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro.
Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S. Drayman N, et al. Among authors: bruce ea. bioRxiv [Preprint]. 2020 Sep 1:2020.08.31.274639. doi: 10.1101/2020.08.31.274639. bioRxiv. 2020. PMID: 32908976 Free PMC article. Updated. Preprint.
Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step.
Bruce EA, Huang ML, Perchetti GA, Tighe S, Laaguiby P, Hoffman JJ, Gerrard DL, Nalla AK, Wei Y, Greninger AL, Diehl SA, Shirley DJ, Leonard DGB, Huston CD, Kirkpatrick BD, Dragon JA, Crothers JW, Jerome KR, Botten JW. Bruce EA, et al. PLoS Biol. 2020 Oct 2;18(10):e3000896. doi: 10.1371/journal.pbio.3000896. eCollection 2020 Oct. PLoS Biol. 2020. PMID: 33006983 Free PMC article.
Kinetics and isotype assessment of antibodies targeting the spike protein receptor-binding domain of severe acute respiratory syndrome-coronavirus-2 in COVID-19 patients as a function of age, biological sex and disease severity.
Graham NR, Whitaker AN, Strother CA, Miles AK, Grier D, McElvany BD, Bruce EA, Poynter ME, Pierce KK, Kirkpatrick BD, Stapleton RD, An G, van den Broek-Altenburg E, Botten JW, Crothers JW, Diehl SA. Graham NR, et al. Among authors: bruce ea. Clin Transl Immunology. 2020 Oct 7;9(10):e1189. doi: 10.1002/cti2.1189. eCollection 2020. Clin Transl Immunology. 2020. PMID: 33072323 Free PMC article.
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses.
Banerjee AK, Blanco MR, Bruce EA, Honson DD, Chen LM, Chow A, Bhat P, Ollikainen N, Quinodoz SA, Loney C, Thai J, Miller ZD, Lin AE, Schmidt MM, Stewart DG, Goldfarb D, De Lorenzo G, Rihn SJ, Voorhees RM, Botten JW, Majumdar D, Guttman M. Banerjee AK, et al. Among authors: bruce ea. Cell. 2020 Nov 25;183(5):1325-1339.e21. doi: 10.1016/j.cell.2020.10.004. Epub 2020 Oct 8. Cell. 2020. PMID: 33080218 Free PMC article.
49 results