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Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington's Disease Patients-A Randomized Phase 2 Clinical Trial.
Brownstein MJ, Simon NG, Long JD, Yankey J, Maibach HT, Cudkowicz M, Coffey C, Conwit RA, Lungu C, Anderson KE, Hersch SM, Ecklund DJ, Damiano EM, Itzkowitz DE, Lu S, Chase MK, Shefner JM, McGarry A, Thornell B, Gladden C, Costigan M, O'Suilleabhain P, Marshall FJ, Chesire AM, Deritis P, Adams JL, Hedera P, Lowen K, Rosas HD, Hiller AL, Quinn J, Keith K, Duker AP, Gruenwald C, Molloy A, Jacob C, Factor S, Sperin E, Bega D, Brown ZR, Seeberger LC, Sung VW, Benge M, Kostyk SK, Daley AM, Perlman S, Suski V, Conlon P, Barrett MJ, Lowenhaupt S, Quigg M, Perlmutter JS, Wright BA, Most E, Schwartz GJ, Lamb J, Chuang RS, Singer C, Marder K, Moran JA, Singleton JR, Zorn M, Wall PV, Dubinsky RM, Gray C, Drazinic C. Brownstein MJ, et al. J Clin Med. 2020 Nov 16;9(11):3682. doi: 10.3390/jcm9113682. J Clin Med. 2020. PMID: 33207828 Free PMC article.
The novel vasopressin receptor (V1aR) antagonist SRX246 reduces anxiety in an experimental model in humans: a randomized proof-of-concept study.
Lago TR, Brownstein MJ, Page E, Beydler E, Manbeck A, Beale A, Roberts C, Balderston N, Damiano E, Pineles SL, Simon N, Ernst M, Grillon C. Lago TR, et al. Among authors: brownstein mj. Psychopharmacology (Berl). 2021 Sep;238(9):2393-2403. doi: 10.1007/s00213-021-05861-4. Epub 2021 May 10. Psychopharmacology (Berl). 2021. PMID: 33970290 Free PMC article. Clinical Trial.
Vasopressin antagonists as anxiolytics and antidepressants: recent developments.
Simon NG, Guillon C, Fabio K, Heindel ND, Lu SF, Miller M, Ferris CF, Brownstein MJ, Garripa C, Koppel GA. Simon NG, et al. Among authors: brownstein mj. Recent Pat CNS Drug Discov. 2008 Jun;3(2):77-93. doi: 10.2174/157488908784534586. Recent Pat CNS Drug Discov. 2008. PMID: 18537767 Review.
Azetidinones as vasopressin V1a antagonists.
Guillon CD, Koppel GA, Brownstein MJ, Chaney MO, Ferris CF, Lu SF, Fabio KM, Miller MJ, Heindel ND, Hunden DC, Cooper RD, Kaldor SW, Skelton JJ, Dressman BA, Clay MP, Steinberg MI, Bruns RF, Simon NG. Guillon CD, et al. Among authors: brownstein mj. Bioorg Med Chem. 2007 Mar 1;15(5):2054-80. doi: 10.1016/j.bmc.2006.12.031. Epub 2006 Dec 23. Bioorg Med Chem. 2007. PMID: 17234419 Free PMC article.
289 results