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Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin.
Brown T, Taherbhai Z, Sexton J, Sutterfield A, Turlington M, Jones J, Stallings L, Stewart M, Buchmueller K, Mackay H, O'hare C, Kluza J, Nguyen B, Wilson D, Lee M, Hartley JA. Brown T, et al. Bioorg Med Chem. 2007 Jan 1;15(1):474-83. doi: 10.1016/j.bmc.2006.09.037. Epub 2006 Oct 10. Bioorg Med Chem. 2007. PMID: 17035029
1,2,3,4-tetrahydro-2-thioxopyrimidine analogs of combretastatin-A4.
Lee L, Davis R, Vanderham J, Hills P, Mackay H, Brown T, Mooberry SL, Lee M. Lee L, et al. Among authors: brown t. Eur J Med Chem. 2008 Sep;43(9):2011-5. doi: 10.1016/j.ejmech.2007.11.030. Epub 2007 Dec 14. Eur J Med Chem. 2008. PMID: 18226429
Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIalpha promoter and modulation of gene expression in cells.
Le NM, Sielaff AM, Cooper AJ, Mackay H, Brown T, Kotecha M, O'Hare C, Hochhauser D, Lee M, Hartley JA. Le NM, et al. Among authors: brown t. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6161-4. doi: 10.1016/j.bmcl.2006.09.043. Epub 2006 Sep 29. Bioorg Med Chem Lett. 2006. PMID: 17011187
Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies.
Mackay H, Brown T, Uthe PB, Westrate L, Sielaff A, Jones J, Lajiness JP, Kluza J, O'Hare C, Nguyen B, Davis Z, Bruce C, Wilson WD, Hartley JA, Lee M. Mackay H, et al. Among authors: brown t. Bioorg Med Chem. 2008 Oct 15;16(20):9145-53. doi: 10.1016/j.bmc.2008.09.034. Epub 2008 Sep 13. Bioorg Med Chem. 2008. PMID: 18819814 Free PMC article.
7,328 results