Brown KW - Search Results

1

The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor.

Legge D, Li L, Moriarty W, Lee D, Szemes M, Zahed A, Panousopoulos L, Chung WY, Aghabi Y, Barratt J, Williams R, Pritchard-Jones K, Malik KTA, Oltean S, Brown KW. Legge D, et al. Among authors: brown kw. Mol Oncol. 2022 Feb;16(3):630-647. doi: 10.1002/1878-0261.13101. Epub 2021 Sep 28. Mol Oncol. 2022. PMID: 34520622 Free PMC article.

2

MYCN is recruited to the RASSF1A promoter but is not critical for DNA hypermethylation in neuroblastoma.

Charlet J, Szemes M, Malik KT, Brown KW. Charlet J, et al. Among authors: brown kw. Mol Carcinog. 2014 May;53(5):413-20. doi: 10.1002/mc.21994. Epub 2012 Dec 31. Mol Carcinog. 2014. PMID: 23280764

3

Genome-wide DNA methylation analysis identifies MEGF10 as a novel epigenetically repressed candidate tumor suppressor gene in neuroblastoma.

Charlet J, Tomari A, Dallosso AR, Szemes M, Kaselova M, Curry TJ, Almutairi B, Etchevers HC, McConville C, Malik KT, Brown KW. Charlet J, et al. Among authors: brown kw. Mol Carcinog. 2017 Apr;56(4):1290-1301. doi: 10.1002/mc.22591. Epub 2016 Nov 29. Mol Carcinog. 2017. PMID: 27862318 Free PMC article.

4

Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours.

Dallosso AR, Hancock AL, Brown KW, Williams AC, Jackson S, Malik K. Dallosso AR, et al. Among authors: brown kw. Hum Mol Genet. 2004 Feb 15;13(4):405-15. doi: 10.1093/hmg/ddh038. Epub 2003 Dec 17. Hum Mol Genet. 2004. PMID: 14681303

5

Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer.

Dallosso AR, Hancock AL, Malik S, Salpekar A, King-Underwood L, Pritchard-Jones K, Peters J, Moorwood K, Ward A, Malik KT, Brown KW. Dallosso AR, et al. Among authors: brown kw. RNA. 2007 Dec;13(12):2287-99. doi: 10.1261/rna.562907. Epub 2007 Oct 16. RNA. 2007. PMID: 17940140 Free PMC article.

6

Frequency and timing of loss of imprinting at 11p13 and 11p15 in Wilms' tumor development.

Brown KW, Power F, Moore B, Charles AK, Malik KT. Brown KW, et al. Mol Cancer Res. 2008 Jul;6(7):1114-23. doi: 10.1158/1541-7786.MCR-08-0002. Mol Cancer Res. 2008. PMID: 18644976

7

Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor.

Dallosso AR, Hancock AL, Szemes M, Moorwood K, Chilukamarri L, Tsai HH, Sarkar A, Barasch J, Vuononvirta R, Jones C, Pritchard-Jones K, Royer-Pokora B, Lee SB, Owen C, Malik S, Feng Y, Frank M, Ward A, Brown KW, Malik K. Dallosso AR, et al. Among authors: brown kw. PLoS Genet. 2009 Nov;5(11):e1000745. doi: 10.1371/journal.pgen.1000745. Epub 2009 Nov 26. PLoS Genet. 2009. PMID: 19956686 Free PMC article.

8

Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.

Szemes M, Dallosso AR, Melegh Z, Curry T, Li Y, Rivers C, Uney J, Mägdefrau AS, Schwiderski K, Park JH, Brown KW, Shandilya J, Roberts SG, Malik K. Szemes M, et al. Among authors: brown kw. Hum Mol Genet. 2013 Jan 1;22(1):74-83. doi: 10.1093/hmg/dds403. Epub 2012 Oct 5. Hum Mol Genet. 2013. PMID: 23042785 Free PMC article.

9

Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells.

Park JH, Szemes M, Vieira GC, Melegh Z, Malik S, Heesom KJ, Von Wallwitz-Freitas L, Greenhough A, Brown KW, Zheng YG, Catchpoole D, Deery MJ, Malik K. Park JH, et al. Among authors: brown kw. Mol Oncol. 2015 Mar;9(3):617-27. doi: 10.1016/j.molonc.2014.10.015. Epub 2014 Nov 15. Mol Oncol. 2015. PMID: 25475372 Free PMC article.

10

Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes.

Almutairi B, Charlet J, Dallosso AR, Szemes M, Etchevers HC, Malik KTA, Brown KW. Almutairi B, et al. Among authors: brown kw. Sci Rep. 2019 Dec 12;9(1):18934. doi: 10.1038/s41598-019-55382-6. Sci Rep. 2019. PMID: 31831790 Free PMC article.

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