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Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines.
Tregoning JS, Stirling DC, Wang Z, Flight KE, Brown JC, Blakney AK, McKay PF, Cunliffe RF, Murugaiah V, Fox CB, Beattie M, Tam YK, Johansson C, Shattock RJ. Tregoning JS, et al. Among authors: brown jc. Mol Ther Nucleic Acids. 2022 Dec 5;31:29-42. doi: 10.1016/j.omtn.2022.11.024. eCollection 2023 Mar 14. Mol Ther Nucleic Acids. 2022. PMID: 36589712 Free PMC article.
Safety and immunogenicity of a self-amplifying RNA vaccine against COVID-19: COVAC1, a phase I, dose-ranging trial.
Pollock KM, Cheeseman HM, Szubert AJ, Libri V, Boffito M, Owen D, Bern H, O'Hara J, McFarlane LR, Lemm NM, McKay PF, Rampling T, Yim YTN, Milinkovic A, Kingsley C, Cole T, Fagerbrink S, Aban M, Tanaka M, Mehdipour S, Robbins A, Budd W, Faust SN, Hassanin H, Cosgrove CA, Winston A, Fidler S, Dunn DT, McCormack S, Shattock RJ; COVAC1 study Group. Pollock KM, et al. EClinicalMedicine. 2022 Feb;44:101262. doi: 10.1016/j.eclinm.2021.101262. Epub 2022 Jan 14. EClinicalMedicine. 2022. PMID: 35043093 Free PMC article.
Polymer formulated self-amplifying RNA vaccine is partially protective against influenza virus infection in ferrets.
McKay PF, Zhou J, Frise R, Blakney AK, Bouton CR, Wang Z, Hu K, Samnuan K, Brown JC, Kugathasan R, Yeow J, Stevens MM, Barclay WS, Tregoning JS, Shattock RJ. McKay PF, et al. Among authors: brown jc. Oxf Open Immunol. 2022 Jun 27;3(1):iqac004. doi: 10.1093/oxfimm/iqac004. eCollection 2022. Oxf Open Immunol. 2022. PMID: 35996628 Free PMC article.
Omicron breakthrough infections in vaccinated or previously infected hamsters.
Zhou J, Sukhova K, Peacock TP, McKay PF, Brown JC, Frise R, Baillon L, Moshe M, Kugathasan R, Shattock RJ, Barclay WS. Zhou J, et al. Among authors: brown jc. Proc Natl Acad Sci U S A. 2023 Nov 7;120(45):e2308655120. doi: 10.1073/pnas.2308655120. Epub 2023 Oct 30. Proc Natl Acad Sci U S A. 2023. PMID: 37903249 Free PMC article.
Propylene glycol inactivates respiratory viruses and prevents airborne transmission.
Styles CT, Zhou J, Flight KE, Brown JC, Lewis C, Wang X, Vanden Oever M, Peacock TP, Wang Z, Millns R, O'Neill JS, Borodavka A, Grove J, Barclay WS, Tregoning JS, Edgar RS. Styles CT, et al. Among authors: brown jc. EMBO Mol Med. 2023 Dec 7;15(12):e17932. doi: 10.15252/emmm.202317932. Epub 2023 Nov 16. EMBO Mol Med. 2023. PMID: 37970627 Free PMC article.
Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence survey.
Flower B, Brown JC, Simmons B, Moshe M, Frise R, Penn R, Kugathasan R, Petersen C, Daunt A, Ashby D, Riley S, Atchison CJ, Taylor GP, Satkunarajah S, Naar L, Klaber R, Badhan A, Rosadas C, Khan M, Fernandez N, Sureda-Vives M, Cheeseman HM, O'Hara J, Fontana G, Pallett SJC, Rayment M, Jones R, Moore LSP, McClure MO, Cherepanov P, Tedder R, Ashrafian H, Shattock R, Ward H, Darzi A, Elliot P, Barclay WS, Cooke GS. Flower B, et al. Among authors: brown jc. Thorax. 2020 Dec;75(12):1082-1088. doi: 10.1136/thoraxjnl-2020-215732. Epub 2020 Aug 12. Thorax. 2020. PMID: 32796119 Free PMC article.
SARS-CoV-2 lateral flow assays for possible use in national covid-19 seroprevalence surveys (React 2): diagnostic accuracy study.
Moshe M, Daunt A, Flower B, Simmons B, Brown JC, Frise R, Penn R, Kugathasan R, Petersen C, Stockmann H, Ashby D, Riley S, Atchison C, Taylor GP, Satkunarajah S, Naar L, Klaber R, Badhan A, Rosadas C, Marchesin F, Fernandez N, Sureda-Vives M, Cheeseman H, O'Hara J, Shattock R, Fontana G, Pallett SJC, Rayment M, Jones R, Moore LSP, Ashrafian H, Cherapanov P, Tedder R, McClure M, Ward H, Darzi A, Elliott P, Cooke GS, Barclay WS; React study team. Moshe M, et al. Among authors: brown jc. BMJ. 2021 Mar 2;372:n423. doi: 10.1136/bmj.n423. BMJ. 2021. PMID: 33653694 Free PMC article.
935 results