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ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1.
Day BW, Stringer BW, Spanevello MD, Charmsaz S, Jamieson PR, Ensbey KS, Carter JC, Cox JM, Ellis VJ, Brown CL, Walker DG, Inglis PL, Allan S, Reynolds BA, Lickliter JD, Boyd AW. Day BW, et al. Among authors: brown cl. Neuro Oncol. 2011 Nov;13(11):1202-12. doi: 10.1093/neuonc/nor119. Epub 2011 Aug 16. Neuro Oncol. 2011. PMID: 21846680 Free PMC article.
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.
Skinner-Adams TS, Stack CM, Trenholme KR, Brown CL, Grembecka J, Lowther J, Mucha A, Drag M, Kafarski P, McGowan S, Whisstock JC, Gardiner DL, Dalton JP. Skinner-Adams TS, et al. Among authors: brown cl. Trends Biochem Sci. 2010 Jan;35(1):53-61. doi: 10.1016/j.tibs.2009.08.004. Epub 2009 Sep 30. Trends Biochem Sci. 2010. PMID: 19796954 Review.
The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.
Skinner-Adams TS, Peatey CL, Anderson K, Trenholme KR, Krige D, Brown CL, Stack C, Nsangou DM, Mathews RT, Thivierge K, Dalton JP, Gardiner DL. Skinner-Adams TS, et al. Among authors: brown cl. Antimicrob Agents Chemother. 2012 Jun;56(6):3244-9. doi: 10.1128/AAC.06245-11. Epub 2012 Mar 26. Antimicrob Agents Chemother. 2012. PMID: 22450967 Free PMC article.
Aminopeptidases of malaria parasites: new targets for chemotherapy.
Trenholme KR, Brown CL, Skinner-Adams TS, Stack C, Lowther J, To J, Robinson MW, Donnelly SM, Dalton JP, Gardiner DL. Trenholme KR, et al. Among authors: brown cl. Infect Disord Drug Targets. 2010 Jun;10(3):217-25. doi: 10.2174/187152610791163363. Infect Disord Drug Targets. 2010. PMID: 20334618 Review.
Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening.
Spicer T, Fernandez-Vega V, Chase P, Scampavia L, To J, Dalton JP, Da Silva FL, Skinner-Adams TS, Gardiner DL, Trenholme KR, Brown CL, Ghosh P, Porubsky P, Wang JL, Whipple DA, Schoenen FJ, Hodder P. Spicer T, et al. Among authors: brown cl. J Biomol Screen. 2014 Aug;19(7):1107-15. doi: 10.1177/1087057114525852. Epub 2014 Mar 11. J Biomol Screen. 2014. PMID: 24619116 Free PMC article.
605 results