Brown CJ - Search Results

1

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.

Lim S, Boyer N, Boo N, Huang C, Venkatachalam G, Angela Juang YC, Garrigou M, Kaan HYK, Duggal R, Peh KM, Sadruddin A, Gopal P, Yuen TY, Ng S, Kannan S, Brown CJ, Verma CS, Orth P, Peier A, Ge L, Yu X, Bhatt B, Chen F, Wang E, Li NJ, Gonzales RJ, Stoeck A, Henry B, Sawyer TK, Lane DP, Johannes CW, Biswas K, Partridge AW. Lim S, et al. Among authors: brown cj. Chem Sci. 2021 Nov 25;12(48):15975-15987. doi: 10.1039/d1sc05187c. eCollection 2021 Dec 15. Chem Sci. 2021. PMID: 35024121 Free PMC article.

2

The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides.

Brown CJ, Srinivasan D, Jun LH, Coomber D, Verma CS, Lane DP. Brown CJ, et al. Cell Cycle. 2008 Mar 1;7(5):608-10. doi: 10.4161/cc.7.5.5488. Epub 2007 Dec 26. Cell Cycle. 2008. PMID: 18256546

3

Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site.

Brown CJ, Verma CS, Walkinshaw MD, Lane DP. Brown CJ, et al. Cell Cycle. 2009 Jun 15;8(12):1905-11. doi: 10.4161/cc.8.12.8742. Epub 2009 Jun 15. Cell Cycle. 2009. PMID: 19440045

4

Design of a novel MDM2 binding peptide based on the p53 family.

Madhumalar A, Lee HJ, Brown CJ, Lane D, Verma C. Madhumalar A, et al. Among authors: brown cj. Cell Cycle. 2009 Sep 1;8(17):2828-36. doi: 10.4161/cc.8.17.9516. Epub 2009 Sep 14. Cell Cycle. 2009. PMID: 19713735

5

Rational design and biophysical characterization of thioredoxin-based aptamers: insights into peptide grafting.

Brown CJ, Dastidar SG, See HY, Coomber DW, Ortiz-Lombardía M, Verma C, Lane DP. Brown CJ, et al. J Mol Biol. 2010 Jan 29;395(4):871-83. doi: 10.1016/j.jmb.2009.10.069. Epub 2009 Nov 3. J Mol Biol. 2010. PMID: 19895821

6

Awakening guardian angels: drugging the p53 pathway.

Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP. Brown CJ, et al. Nat Rev Cancer. 2009 Dec;9(12):862-73. doi: 10.1038/nrc2763. Nat Rev Cancer. 2009. PMID: 19935675 Review.

7

Mdm2 and p53 are highly conserved from placozoans to man.

Lane DP, Cheok CF, Brown C, Madhumalar A, Ghadessy FJ, Verma C. Lane DP, et al. Cell Cycle. 2010 Feb 1;9(3):540-7. doi: 10.4161/cc.9.3.10516. Cell Cycle. 2010. PMID: 20081368

8

The Mdm2 and p53 genes are conserved in the Arachnids.

Lane DP, Cheok CF, Brown CJ, Madhumalar A, Ghadessy FJ, Verma C. Lane DP, et al. Among authors: brown cj. Cell Cycle. 2010 Feb 15;9(4):748-54. doi: 10.4161/cc.9.4.10616. Epub 2010 Feb 12. Cell Cycle. 2010. PMID: 20160485

9

Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.

Joseph TL, Madhumalar A, Brown CJ, Lane DP, Verma CS. Joseph TL, et al. Among authors: brown cj. Cell Cycle. 2010 Mar 15;9(6):1167-81. doi: 10.4161/cc.9.6.11067. Epub 2010 Mar 15. Cell Cycle. 2010. PMID: 20190571

10

Stabilizing the eIF4G1 α-helix increases its binding affinity with eIF4E: implications for peptidomimetic design strategies.

Brown CJ, Lim JJ, Leonard T, Lim HC, Chia CS, Verma CS, Lane DP. Brown CJ, et al. J Mol Biol. 2011 Jan 21;405(3):736-53. doi: 10.1016/j.jmb.2010.10.045. Epub 2010 Nov 19. J Mol Biol. 2011. PMID: 21094167

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