Brown CJ - Search Results

1

Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

Sawyer TK, Partridge AW, Kaan HYK, Juang YC, Lim S, Johannes C, Yuen TY, Verma C, Kannan S, Aronica P, Tan YS, Sherborne B, Ha S, Hochman J, Chen S, Surdi L, Peier A, Sauvagnat B, Dandliker PJ, Brown CJ, Ng S, Ferrer F, Lane DP. Sawyer TK, et al. Among authors: brown cj. Bioorg Med Chem. 2018 Jun 1;26(10):2807-2815. doi: 10.1016/j.bmc.2018.03.008. Epub 2018 Mar 16. Bioorg Med Chem. 2018. PMID: 29598901

2

The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides.

Brown CJ, Srinivasan D, Jun LH, Coomber D, Verma CS, Lane DP. Brown CJ, et al. Cell Cycle. 2008 Mar 1;7(5):608-10. doi: 10.4161/cc.7.5.5488. Epub 2007 Dec 26. Cell Cycle. 2008. PMID: 18256546

3

Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site.

Brown CJ, Verma CS, Walkinshaw MD, Lane DP. Brown CJ, et al. Cell Cycle. 2009 Jun 15;8(12):1905-11. doi: 10.4161/cc.8.12.8742. Epub 2009 Jun 15. Cell Cycle. 2009. PMID: 19440045

4

Design of a novel MDM2 binding peptide based on the p53 family.

Madhumalar A, Lee HJ, Brown CJ, Lane D, Verma C. Madhumalar A, et al. Among authors: brown cj. Cell Cycle. 2009 Sep 1;8(17):2828-36. doi: 10.4161/cc.8.17.9516. Epub 2009 Sep 14. Cell Cycle. 2009. PMID: 19713735

5

Rational design and biophysical characterization of thioredoxin-based aptamers: insights into peptide grafting.

Brown CJ, Dastidar SG, See HY, Coomber DW, Ortiz-Lombardía M, Verma C, Lane DP. Brown CJ, et al. J Mol Biol. 2010 Jan 29;395(4):871-83. doi: 10.1016/j.jmb.2009.10.069. Epub 2009 Nov 3. J Mol Biol. 2010. PMID: 19895821

6

Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL.

Wan KF, Wang S, Brown CJ, Yu VC, Entzeroth M, Lane DP, Lee MA. Wan KF, et al. Among authors: brown cj. Cell Cycle. 2009 Dec;8(23):3943-52. doi: 10.4161/cc.8.23.10114. Epub 2009 Dec 17. Cell Cycle. 2009. PMID: 19901550

7

Awakening guardian angels: drugging the p53 pathway.

Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP. Brown CJ, et al. Nat Rev Cancer. 2009 Dec;9(12):862-73. doi: 10.1038/nrc2763. Nat Rev Cancer. 2009. PMID: 19935675 Review.

8

Mdm2 and p53 are highly conserved from placozoans to man.

Lane DP, Cheok CF, Brown C, Madhumalar A, Ghadessy FJ, Verma C. Lane DP, et al. Cell Cycle. 2010 Feb 1;9(3):540-7. doi: 10.4161/cc.9.3.10516. Cell Cycle. 2010. PMID: 20081368

9

The Mdm2 and p53 genes are conserved in the Arachnids.

Lane DP, Cheok CF, Brown CJ, Madhumalar A, Ghadessy FJ, Verma C. Lane DP, et al. Among authors: brown cj. Cell Cycle. 2010 Feb 15;9(4):748-54. doi: 10.4161/cc.9.4.10616. Epub 2010 Feb 12. Cell Cycle. 2010. PMID: 20160485

10

Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.

Joseph TL, Madhumalar A, Brown CJ, Lane DP, Verma CS. Joseph TL, et al. Among authors: brown cj. Cell Cycle. 2010 Mar 15;9(6):1167-81. doi: 10.4161/cc.9.6.11067. Epub 2010 Mar 15. Cell Cycle. 2010. PMID: 20190571

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