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A novel somatostatin receptor ligand for human ACTH - and GH -secreting pituitary adenomas.
Regazzo D, Avallone S, MacSweeney CP, Sergeev E, Howe D, Godwood A, Bennett KA, Brown AJH, Barnes M, Occhi G, Barbot M, Faggian D, Tropeano MP, Losa M, Lasio G, Scaroni C, Pecori Giraldi F. Regazzo D, et al. Among authors: brown ajh. Eur J Endocrinol. 2024 Jan 3;190(1):K8-K16. doi: 10.1093/ejendo/lvad171. Eur J Endocrinol. 2024. PMID: 38123488 Free article.
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.
Nathan PJ, Millais SB, Godwood A, Dewit O, Cross DM, Liptrot J, Ruparelia B, Jones SP, Bakker G, Maruff PT, Light GA, Brown AJH, Weir MP, Congreve M, Tasker T. Nathan PJ, et al. Among authors: brown ajh. Alzheimers Dement (N Y). 2022 Feb 23;8(1):e12273. doi: 10.1002/trc2.12273. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 35229025 Free PMC article.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB. Brown AJH, et al. Cell. 2021 Nov 24;184(24):5886-5901.e22. doi: 10.1016/j.cell.2021.11.001. Cell. 2021. PMID: 34822784 Free article. Clinical Trial.
In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA.
Nyimanu D, Kay RG, Kuc RE, Brown AJH, Gribble FM, Maguire JJ, Davenport AP. Nyimanu D, et al. Among authors: brown ajh. Peptides. 2021 Nov;145:170642. doi: 10.1016/j.peptides.2021.170642. Epub 2021 Aug 26. Peptides. 2021. PMID: 34455010 Free PMC article.
29 results