Brouwer KLR - Search Results

1

Clinical Relevance of Hepatic and Renal P-gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective.

Taskar KS, Yang X, Neuhoff S, Patel M, Yoshida K, Paine MF, Brouwer KLR, Chu X, Sugiyama Y, Cook J, Polli JW, Hanna I, Lai Y, Zamek-Gliszczynski M; ITC. Taskar KS, et al. Among authors: brouwer klr. Clin Pharmacol Ther. 2022 Sep;112(3):573-592. doi: 10.1002/cpt.2670. Epub 2022 Jun 22. Clin Pharmacol Ther. 2022. PMID: 35612761 Free PMC article. Review.

2

Altered hepatobiliary disposition of acetaminophen metabolites after phenobarbital pretreatment and renal ligation: evidence for impaired biliary excretion and a diffusional barrier.

Brouwer KL, Jones JA. Brouwer KL, et al. J Pharmacol Exp Ther. 1990 Feb;252(2):657-64. J Pharmacol Exp Ther. 1990. PMID: 2313593

3

P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells.

Letrent SP, Polli JW, Humphreys JE, Pollack GM, Brouwer KR, Brouwer KL. Letrent SP, et al. Biochem Pharmacol. 1999 Sep 15;58(6):951-7. doi: 10.1016/s0006-2952(99)00180-x. Biochem Pharmacol. 1999. PMID: 10509747

4

Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats.

Xiong H, Turner KC, Ward ES, Jansen PL, Brouwer KL. Xiong H, et al. J Pharmacol Exp Ther. 2000 Nov;295(2):512-8. J Pharmacol Exp Ther. 2000. PMID: 11046083

5

Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment.

Xiong H, Suzuki H, Sugiyama Y, Meier PJ, Pollack GM, Brouwer KL. Xiong H, et al. Drug Metab Dispos. 2002 Sep;30(9):962-9. doi: 10.1124/dmd.30.9.962. Drug Metab Dispos. 2002. PMID: 12167560

6

Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers.

Lee K, Ng C, Brouwer KL, Thakker DR. Lee K, et al. J Pharmacol Exp Ther. 2002 Nov;303(2):574-80. doi: 10.1124/jpet.102.038521. J Pharmacol Exp Ther. 2002. PMID: 12388638

7

Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver.

Zamek-Gliszczynski MJ, Xiong H, Patel NJ, Turncliff RZ, Pollack GM, Brouwer KL. Zamek-Gliszczynski MJ, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):801-9. doi: 10.1124/jpet.102.044107. J Pharmacol Exp Ther. 2003. PMID: 12538836

8

Cytokine regulation of P-glycoprotein.

McRae MP, Brouwer KL, Kashuba AD. McRae MP, et al. Drug Metab Rev. 2003 Feb;35(1):19-33. doi: 10.1081/dmr-120018247. Drug Metab Rev. 2003. PMID: 12635814 Review.

9

Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions.

Patel NJ, Zamek-Gliszczynski MJ, Zhang P, Han YH, Jansen PL, Meier PJ, Stieger B, Brouwer KL. Patel NJ, et al. Mol Pharmacol. 2003 Jul;64(1):154-9. doi: 10.1124/mol.64.1.154. Mol Pharmacol. 2003. PMID: 12815171

10

Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems.

Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, Brouwer KL. Hoffmaster KA, et al. J Pharmacol Exp Ther. 2004 Dec;311(3):1203-10. doi: 10.1124/jpet.104.070201. Epub 2004 Aug 9. J Pharmacol Exp Ther. 2004. PMID: 15302892

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