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Page 1
Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia.
Kan WL, Dhagat U, Kaufmann KB, Hercus TR, Nero TL, Zeng AGX, Toubia J, Barry EF, Broughton SE, Gomez GA, Benard BA, Dottore M, Cheung Tung Shing KS, Boutzen H, Samaraweera SE, Simpson KJ, Jin L, Goodall GJ, Begley CG, Thomas D, Ekert PG, Tvorogov D, D'Andrea RJ, Dick JE, Parker MW, Lopez AF. Kan WL, et al. Among authors: broughton se. Cancer Discov. 2023 Aug 4;13(8):1922-1947. doi: 10.1158/2159-8290.CD-22-1396. Cancer Discov. 2023. PMID: 37191437 Free PMC article.
The GM-CSF receptor family: mechanism of activation and implications for disease.
Hercus TR, Broughton SE, Ekert PG, Ramshaw HS, Perugini M, Grimbaldeston M, Woodcock JM, Thomas D, Pitson S, Hughes T, D'Andrea RJ, Parker MW, Lopez AF. Hercus TR, et al. Among authors: broughton se. Growth Factors. 2012 Apr;30(2):63-75. doi: 10.3109/08977194.2011.649919. Epub 2012 Jan 18. Growth Factors. 2012. PMID: 22257375 Review.
Cytokine receptor activation at the cell surface.
Broughton SE, Hercus TR, Lopez AF, Parker MW. Broughton SE, et al. Curr Opin Struct Biol. 2012 Jun;22(3):350-9. doi: 10.1016/j.sbi.2012.03.015. Epub 2012 Apr 20. Curr Opin Struct Biol. 2012. PMID: 22521507 Review.
Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.
Broughton SE, Hercus TR, Nero TL, Dhagat U, Owczarek CM, Hardy MP, Fabri LJ, Scotney PD, Nash AD, Wilson NJ, Lopez AF, Parker MW. Broughton SE, et al. Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):358-61. doi: 10.1107/S2053230X14002593. Epub 2014 Feb 19. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24598927 Free PMC article.
Unexpected mechanisms of action for a cytokine receptor-blocking antibody.
Hercus TR, Broughton SE, Hardy MP, Nero TL, Wilson NJ, Parker MW, Lopez AF. Hercus TR, et al. Among authors: broughton se. Mol Cell Oncol. 2014 Dec 31;1(4):e969129. doi: 10.4161/23288604.2014.969129. eCollection 2014 Oct-Dec. Mol Cell Oncol. 2014. PMID: 27308368 Free PMC article.
Signalling by the βc family of cytokines.
Hercus TR, Dhagat U, Kan WL, Broughton SE, Nero TL, Perugini M, Sandow JJ, D'Andrea RJ, Ekert PG, Hughes T, Parker MW, Lopez AF. Hercus TR, et al. Among authors: broughton se. Cytokine Growth Factor Rev. 2013 Jun;24(3):189-201. doi: 10.1016/j.cytogfr.2013.03.002. Epub 2013 Mar 25. Cytokine Growth Factor Rev. 2013. PMID: 23535386 Review.
Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.
Broughton SE, Hercus TR, Hardy MP, McClure BJ, Nero TL, Dottore M, Huynh H, Braley H, Barry EF, Kan WL, Dhagat U, Scotney P, Hartman D, Busfield SJ, Owczarek CM, Nash AD, Wilson NJ, Parker MW, Lopez AF. Broughton SE, et al. Cell Rep. 2014 Jul 24;8(2):410-9. doi: 10.1016/j.celrep.2014.06.038. Epub 2014 Jul 17. Cell Rep. 2014. PMID: 25043189 Free article.
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