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Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance.
Xirouchaki CE, Jia Y, McGrath MJ, Greatorex S, Tran M, Merry TL, Hong D, Eramo MJ, Broome SC, Woodhead JST, D'souza RF, Gallagher J, Salimova E, Huang C, Schittenhelm RB, Sadoshima J, Watt MJ, Mitchell CA, Tiganis T. Xirouchaki CE, et al. Among authors: broome sc. Sci Adv. 2021 Dec 17;7(51):eabl4988. doi: 10.1126/sciadv.abl4988. Epub 2021 Dec 15. Sci Adv. 2021. PMID: 34910515 Free PMC article.
Mitochondria-targeted antioxidant supplementation does not affect muscle soreness or recovery of maximal voluntary isometric contraction force following muscle-damaging exercise in untrained men: a randomized clinical trial.
Broome SC, Atiola RD, Braakhuis AJ, Mitchell CJ, Merry TL. Broome SC, et al. Appl Physiol Nutr Metab. 2022 Jul 1;47(7):762-774. doi: 10.1139/apnm-2021-0767. Epub 2022 Feb 24. Appl Physiol Nutr Metab. 2022. PMID: 35201920 Clinical Trial.
MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men.
Broome SC, Pham T, Braakhuis AJ, Narang R, Wang HW, Hickey AJR, Mitchell CJ, Merry TL. Broome SC, et al. Redox Biol. 2022 Jul;53:102341. doi: 10.1016/j.redox.2022.102341. Epub 2022 May 20. Redox Biol. 2022. PMID: 35623315 Free PMC article. Clinical Trial.
A role for β-catenin in diet-induced skeletal muscle insulin resistance.
Masson SWC, Dissanayake WC, Broome SC, Hedges CP, Peeters WM, Gram M, Rowlands DS, Shepherd PR, Merry TL. Masson SWC, et al. Among authors: broome sc. Physiol Rep. 2023 Feb;11(4):e15536. doi: 10.14814/phy2.15536. Physiol Rep. 2023. PMID: 36807886 Free PMC article.
Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice.
Hedges CP, Shetty B, Broome SC, MacRae C, Koutsifeli P, Buckels EJ, MacIndoe C, Boix J, Tsiloulis T, Matthews BG, Sinha S, Arendse M, Jaiswal JK, Mellor KM, Hickey AJR, Shepherd PR, Merry TL. Hedges CP, et al. Among authors: broome sc. Nat Aging. 2023 Feb;3(2):162-172. doi: 10.1038/s43587-022-00349-y. Epub 2023 Jan 23. Nat Aging. 2023. PMID: 37118113
15 results