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Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging.
Dorronsoro A, Santiago FE, Grassi D, Zhang T, Lai RC, McGowan SJ, Angelini L, Lavasani M, Corbo L, Lu A, Brooks RW, Garcia-Contreras M, Stolz DB, Amelio A, Boregowda SV, Fallahi M, Reich A, Ricordi C, Phinney DG, Huard J, Lim SK, Niedernhofer LJ, Robbins PD. Dorronsoro A, et al. Among authors: brooks rw. Aging Cell. 2021 Apr;20(4):e13337. doi: 10.1111/acel.13337. Epub 2021 Mar 16. Aging Cell. 2021. PMID: 33728821 Free PMC article.
Identification of HSP90 inhibitors as a novel class of senolytics.
Fuhrmann-Stroissnigg H, Ling YY, Zhao J, McGowan SJ, Zhu Y, Brooks RW, Grassi D, Gregg SQ, Stripay JL, Dorronsoro A, Corbo L, Tang P, Bukata C, Ring N, Giacca M, Li X, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD. Fuhrmann-Stroissnigg H, et al. Among authors: brooks rw. Nat Commun. 2017 Sep 4;8(1):422. doi: 10.1038/s41467-017-00314-z. Nat Commun. 2017. PMID: 28871086 Free PMC article.
An aged immune system drives senescence and ageing of solid organs.
Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O'Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ. Yousefzadeh MJ, et al. Among authors: brooks rw. Nature. 2021 Jun;594(7861):100-105. doi: 10.1038/s41586-021-03547-7. Epub 2021 May 12. Nature. 2021. PMID: 33981041 Free PMC article.
Cellular senescence mediates fibrotic pulmonary disease.
Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK. Schafer MJ, et al. Among authors: brooks rw. Nat Commun. 2017 Feb 23;8:14532. doi: 10.1038/ncomms14532. Nat Commun. 2017. PMID: 28230051 Free PMC article.
The bedfast.
Rowe J, Milnes JP, Hill SN, Allen-Narker RA, Brooks RW, Desai HN, Dunn AM, Hewetson K, Howard DJ, Misra KK, et al. Rowe J, et al. Among authors: brooks rw. Int Disabil Stud. 1987;9(1):15-7. doi: 10.3109/02599148709166221. Int Disabil Stud. 1987. PMID: 3117766
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