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C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle.
Kinast V, Plociennikowska A, Anggakusuma, Bracht T, Todt D, Brown RJP, Boldanova T, Zhang Y, Brüggemann Y, Friesland M, Engelmann M, Vieyres G, Broering R, Vondran FWR, Heim MH, Sitek B, Bartenschlager R, Pietschmann T, Steinmann E. Kinast V, et al. Among authors: broering r. J Hepatol. 2020 Sep;73(3):549-558. doi: 10.1016/j.jhep.2020.03.047. Epub 2020 Apr 12. J Hepatol. 2020. PMID: 32294532 Free article.
Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements.
Tegtmeyer B, Vieyres G, Todt D, Lauber C, Ginkel C, Engelmann M, Herrmann M, Pfaller CK, Vondran FWR, Broering R, Vafadarnejad E, Saliba AE, Puff C, Baumgärtner W, Miskey C, Ivics Z, Steinmann E, Pietschmann T, Brown RJP. Tegtmeyer B, et al. Among authors: broering r. J Virol. 2021 Apr 26;95(10):e00245-21. doi: 10.1128/JVI.00245-21. Epub 2021 Mar 3. J Virol. 2021. PMID: 33658347 Free PMC article.
A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function.
Meister TL, Brüggemann Y, Nocke MK, Ulrich RG, Schuhenn J, Sutter K, Gömer A, Bader V, Winklhofer KF, Broering R, Verhoye L, Meuleman P, Vondran FWR, Camuzet C, Cocquerel L, Todt D, Steinmann E. Meister TL, et al. Among authors: broering r. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2202653119. doi: 10.1073/pnas.2202653119. Epub 2022 Aug 15. Proc Natl Acad Sci U S A. 2022. PMID: 35969792 Free PMC article.
EGF receptor modulates HEV entry in human hepatocytes.
Schrader JA, Burkard TL, Brüggemann Y, Gömer A, Meister TL, Fu RM, Mehnert AK, Dao Thi VL, Behrendt P, Durantel D, Broering R, Vondran FWR, Todt D, Kinast V, Steinmann E. Schrader JA, et al. Among authors: broering r. Hepatology. 2023 Jun 1;77(6):2104-2117. doi: 10.1097/HEP.0000000000000308. Epub 2023 Feb 7. Hepatology. 2023. PMID: 36745934 Free PMC article.
Janus kinase-inhibition modulates hepatitis E virus infection.
Kinast V, Andreica I, Ahrenstorf G, Gömer A, Elsner C, Schlienkamp S, Schrader JA, Klöhn M, Ulrich RG, Broering R, Vondran FWR, Todt D, Behrendt P, Dittmer U, Hamprecht A, Witte T, Baraliakos X, Steinmann E. Kinast V, et al. Among authors: broering r. Antiviral Res. 2023 Sep;217:105690. doi: 10.1016/j.antiviral.2023.105690. Epub 2023 Jul 28. Antiviral Res. 2023. PMID: 37517633 Free article.
Autoimmune hepatitis induction can occur in the liver.
Dywicki J, Buitrago-Molina LE, Pietrek J, Lieber M, Broering R, Khera T, Schlue J, Manns MP, Wedemeyer H, Jaeckel E, Hardtke-Wolenski M. Dywicki J, et al. Among authors: broering r. Liver Int. 2020 Feb;40(2):377-381. doi: 10.1111/liv.14296. Epub 2019 Dec 1. Liver Int. 2020. PMID: 31724273
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