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Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
Handratta VD, Vasaitis TS, Njar VC, Gediya LK, Kataria R, Chopra P, Newman D Jr, Farquhar R, Guo Z, Qiu Y, Brodie AM. Handratta VD, et al. Among authors: brodie am. J Med Chem. 2005 Apr 21;48(8):2972-84. doi: 10.1021/jm040202w. J Med Chem. 2005. PMID: 15828836
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer.
Vasaitis T, Belosay A, Schayowitz A, Khandelwal A, Chopra P, Gediya LK, Guo Z, Fang HB, Njar VC, Brodie AM. Vasaitis T, et al. Among authors: brodie am. Mol Cancer Ther. 2008 Aug;7(8):2348-57. doi: 10.1158/1535-7163.MCT-08-0230. Mol Cancer Ther. 2008. PMID: 18723482 Free PMC article.
Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.
Bruno RD, Vasaitis TS, Gediya LK, Purushottamachar P, Godbole AM, Ates-Alagoz Z, Brodie AM, Njar VC. Bruno RD, et al. Among authors: brodie am. Steroids. 2011 Nov;76(12):1268-79. doi: 10.1016/j.steroids.2011.06.002. Epub 2011 Jun 24. Steroids. 2011. PMID: 21729712 Free PMC article.
Regulation of androgen receptor activity by tyrosine phosphorylation.
Guo Z, Dai B, Jiang T, Xu K, Xie Y, Kim O, Nesheiwat I, Kong X, Melamed J, Handratta VD, Njar VC, Brodie AM, Yu LR, Veenstra TD, Chen H, Qiu Y. Guo Z, et al. Among authors: brodie am. Cancer Cell. 2006 Oct;10(4):309-19. doi: 10.1016/j.ccr.2006.08.021. Cancer Cell. 2006. PMID: 17045208 Free article.
163 results