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Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors.
Tietjen I, Ntie-Kang F, Mwimanzi P, Onguéné PA, Scull MA, Idowu TO, Ogundaini AO, Meva'a LM, Abegaz BM, Rice CM, Andrae-Marobela K, Brockman MA, Brumme ZL, Fedida D. Tietjen I, et al. Among authors: brockman ma. PLoS One. 2015 Apr 1;10(4):e0121099. doi: 10.1371/journal.pone.0121099. eCollection 2015. PLoS One. 2015. PMID: 25830320 Free PMC article.
Croton megalobotrys Müll Arg. and Vitex doniana (Sweet): Traditional medicinal plants in a three-step treatment regimen that inhibit in vitro replication of HIV-1.
Tietjen I, Gatonye T, Ngwenya BN, Namushe A, Simonambanga S, Muzila M, Mwimanzi P, Xiao J, Fedida D, Brumme ZL, Brockman MA, Andrae-Marobela K. Tietjen I, et al. Among authors: brockman ma. J Ethnopharmacol. 2016 Sep 15;191:331-340. doi: 10.1016/j.jep.2016.06.040. Epub 2016 Jun 24. J Ethnopharmacol. 2016. PMID: 27350006
Novel Acylguanidine-Based Inhibitor of HIV-1.
Mwimanzi P, Tietjen I, Miller SC, Shahid A, Cobarrubias K, Kinloch NN, Baraki B, Richard J, Finzi A, Fedida D, Brumme ZL, Brockman MA. Mwimanzi P, et al. Among authors: brockman ma. J Virol. 2016 Sep 29;90(20):9495-508. doi: 10.1128/JVI.01107-16. Print 2016 Oct 15. J Virol. 2016. PMID: 27512074 Free PMC article.
The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.
Tietjen I, Ngwenya BN, Fotso G, Williams DE, Simonambango S, Ngadjui BT, Andersen RJ, Brockman MA, Brumme ZL, Andrae-Marobela K. Tietjen I, et al. Among authors: brockman ma. J Ethnopharmacol. 2018 Jan 30;211:267-277. doi: 10.1016/j.jep.2017.09.038. Epub 2017 Sep 29. J Ethnopharmacol. 2018. PMID: 28970153
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.
Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B, Andersen RJ, Brumme ZL, Brockman MA. Tietjen I, et al. Among authors: brockman ma. Antiviral Res. 2018 Apr;152:94-103. doi: 10.1016/j.antiviral.2018.02.017. Epub 2018 Feb 22. Antiviral Res. 2018. PMID: 29476895
The African natural product knipholone anthrone and its analogue anthralin (dithranol) enhance HIV-1 latency reversal.
Richard K, Schonhofer C, Giron LB, Rivera-Ortiz J, Read S, Kannan T, Kinloch NN, Shahid A, Feilcke R, Wappler S, Imming P, Harris M, Brumme ZL, Brockman MA, Mounzer K, Kossenkov AV, Abdel-Mohsen M, Andrae-Marobela K, Montaner LJ, Tietjen I. Richard K, et al. Among authors: brockman ma. J Biol Chem. 2020 Oct 9;295(41):14084-14099. doi: 10.1074/jbc.RA120.013031. Epub 2020 Aug 11. J Biol Chem. 2020. PMID: 32788215 Free PMC article.
Flavonoid-based inhibition of cyclin-dependent kinase 9 without concomitant inhibition of histone deacetylases durably reinforces HIV latency.
Schonhofer C, Yi J, Sciorillo A, Andrae-Marobela K, Cochrane A, Harris M, Brumme ZL, Brockman MA, Mounzer K, Hart C, Gyampoh K, Yuan Z, Montaner LJ, Tietjen I. Schonhofer C, et al. Among authors: brockman ma. Biochem Pharmacol. 2021 Apr;186:114462. doi: 10.1016/j.bcp.2021.114462. Epub 2021 Feb 10. Biochem Pharmacol. 2021. PMID: 33577894 Free PMC article.
149 results