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T cell activation is insufficient to drive SIV disease progression.
Apetrei C, Gaufin T, Brocca-Cofano E, Sivanandham R, Sette P, He T, Sivanandham S, Martinez Sosa N, Martin KJ, Raehtz KD, Kleinman AJ, Valentine A, Krampe N, Gautam R, Lackner AA, Landay AL, Ribeiro RM, Pandrea I. Apetrei C, et al. Among authors: brocca cofano e. JCI Insight. 2023 Jul 24;8(14):e161111. doi: 10.1172/jci.insight.161111. JCI Insight. 2023. PMID: 37485874 Free PMC article.
Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys.
Le Hingrat Q, Sette P, Xu C, Rahmberg AR, Tarnus L, Annapureddy H, Kleinman A, Brocca-Cofano E, Sivanandham R, Sivanandham S, He T, Capreri DJ, Ma D, Estes JD, Brenchley JM, Apetrei C, Pandrea I. Le Hingrat Q, et al. Among authors: brocca cofano e. Nat Commun. 2023 Feb 22;14(1):979. doi: 10.1038/s41467-023-36379-2. Nat Commun. 2023. PMID: 36813761 Free PMC article.
Changes to the Simian Immunodeficiency Virus (SIV) Reservoir and Enhanced SIV-Specific Responses in a Rhesus Macaque Model of Functional Cure after Serial Rounds of Romidepsin Administrations.
Kleinman AJ, Sivanandham S, Sette P, Sivanandham R, Policicchio BB, Xu C, Penn E, Brocca-Cofano E, Le Hingrat Q, Ma D, Pandrea I, Apetrei C. Kleinman AJ, et al. Among authors: brocca cofano e. J Virol. 2022 Jun 22;96(12):e0044522. doi: 10.1128/jvi.00445-22. Epub 2022 May 31. J Virol. 2022. PMID: 35638831 Free PMC article.
Lack of Specific Regulatory T Cell Depletion and Cytoreduction Associated with Extensive Toxicity After Administration of Low and High Doses of Cyclophosphamide.
Kleinman AJ, Sivanandham R, Sette P, Brocca-Cofano E, McAndrews C, Keele BF, Pandrea I, Apetrei C. Kleinman AJ, et al. Among authors: brocca cofano e. AIDS Res Hum Retroviruses. 2022 Jan;38(1):45-49. doi: 10.1089/AID.2021.0036. Epub 2021 Jun 8. AIDS Res Hum Retroviruses. 2022. PMID: 33957772 Free PMC article.
Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques.
Kleinman AJ, Xu C, Cottrell ML, Sivanandham R, Brocca-Cofano E, Dunsmore T, Kashuba A, Pandrea I, Apetrei C. Kleinman AJ, et al. Among authors: brocca cofano e. Front Immunol. 2020 Dec 11;11:579158. doi: 10.3389/fimmu.2020.579158. eCollection 2020. Front Immunol. 2020. PMID: 33362765 Free PMC article.
Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus.
Sivanandham R, Kleinman AJ, Sette P, Brocca-Cofano E, Kilapandal Venkatraman SM, Policicchio BB, He T, Xu C, Swarthout J, Wang Z, Pandrea I, Apetrei C. Sivanandham R, et al. Among authors: brocca cofano e. J Virol. 2020 Sep 15;94(19):e00533-20. doi: 10.1128/JVI.00533-20. Print 2020 Sep 15. J Virol. 2020. PMID: 32669326 Free PMC article.
African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity.
Raehtz KD, Barrenäs F, Xu C, Busman-Sahay K, Valentine A, Law L, Ma D, Policicchio BB, Wijewardana V, Brocca-Cofano E, Trichel A, Gale M Jr, Keele BF, Estes JD, Apetrei C, Pandrea I. Raehtz KD, et al. Among authors: brocca cofano e. PLoS Pathog. 2020 Mar 2;16(3):e1008333. doi: 10.1371/journal.ppat.1008333. eCollection 2020 Mar. PLoS Pathog. 2020. PMID: 32119719 Free PMC article.
Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques.
Brocca-Cofano E, Xu C, Wetzel KS, Cottrell ML, Policicchio BB, Raehtz KD, Ma D, Dunsmore T, Haret-Richter GS, Musaitif K, Keele BF, Kashuba AD, Collman RG, Pandrea I, Apetrei C. Brocca-Cofano E, et al. J Virol. 2018 Aug 16;92(17):e00576-18. doi: 10.1128/JVI.00576-18. Print 2018 Sep 1. J Virol. 2018. PMID: 29925666 Free PMC article.
42 results