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Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Bradley SJ, Molloy C, Valuskova P, Dwomoh L, Scarpa M, Rossi M, Finlayson L, Svensson KA, Chernet E, Barth VN, Gherbi K, Sykes DA, Wilson CA, Mistry R, Sexton PM, Christopoulos A, Mogg AJ, Rosethorne EM, Sakata S, John Challiss RA, Broad LM, Tobin AB. Bradley SJ, et al. Among authors: broad lm. Nat Chem Biol. 2020 Mar;16(3):240-249. doi: 10.1038/s41589-019-0453-9. Epub 2020 Feb 20. Nat Chem Biol. 2020. PMID: 32080630 Free article.
Epibatidine isomers and analogues: structure-activity relationships.
White R, Malpass JR, Handa S, Richard Baker S, Broad LM, Folly L, Mogg A. White R, et al. Among authors: broad lm. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7. doi: 10.1016/j.bmcl.2006.08.049. Epub 2006 Aug 28. Bioorg Med Chem Lett. 2006. PMID: 16934977
TRP channels as emerging targets for pain therapeutics.
Broad LM, Mogg AJ, Beattie RE, Ogden AM, Blanco MJ, Bleakman D. Broad LM, et al. Expert Opin Ther Targets. 2009 Jan;13(1):69-81. doi: 10.1517/14728220802616620. Expert Opin Ther Targets. 2009. PMID: 19063707 Review.
Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons.
Dage JL, Colvin EM, Fouillet A, Langron E, Roell WC, Li J, Mathur SX, Mogg AJ, Schmitt MG, Felder CC, Merchant KM, Isaac J, Broad LM, Sher E, Ursu D. Dage JL, et al. Among authors: broad lm. Psychopharmacology (Berl). 2014 Mar;231(6):1105-24. doi: 10.1007/s00213-013-3384-2. Epub 2014 Jan 16. Psychopharmacology (Berl). 2014. PMID: 24429870
123I-iododexetimide preferentially binds to the muscarinic receptor subtype M1 in vivo.
Bakker G, Vingerhoets WA, van Wieringen JP, de Bruin K, Eersels J, de Jong J, Chahid Y, Rutten BP, DuBois S, Watson M, Mogg AJ, Xiao H, Crabtree M, Collier DA, Felder CC, Barth VN, Broad LM, Bloemen OJ, van Amelsvoort TA, Booij J. Bakker G, et al. Among authors: broad lm. J Nucl Med. 2015 Feb;56(2):317-22. doi: 10.2967/jnumed.114.147488. Epub 2015 Jan 15. J Nucl Med. 2015. PMID: 25593117 Free article.
An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.
Butcher AJ, Bradley SJ, Prihandoko R, Brooke SM, Mogg A, Bourgognon JM, Macedo-Hatch T, Edwards JM, Bottrill AR, Challiss RA, Broad LM, Felder CC, Tobin AB. Butcher AJ, et al. Among authors: broad lm. J Biol Chem. 2016 Apr 22;291(17):8862-75. doi: 10.1074/jbc.M115.681726. Epub 2016 Jan 29. J Biol Chem. 2016. PMID: 26826123 Free PMC article.
56 results