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IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption.
Langer V, Vivi E, Regensburger D, Winkler TH, Waldner MJ, Rath T, Schmid B, Skottke L, Lee S, Jeon NL, Wohlfahrt T, Kramer V, Tripal P, Schumann M, Kersting S, Handtrack C, Geppert CI, Suchowski K, Adams RH, Becker C, Ramming A, Naschberger E, Britzen-Laurent N, Stürzl M. Langer V, et al. J Clin Invest. 2019 Nov 1;129(11):4691-4707. doi: 10.1172/JCI124884. J Clin Invest. 2019. PMID: 31566580 Free PMC article. Clinical Trial.
GBP-1 acts as a tumor suppressor in colorectal cancer cells.
Britzen-Laurent N, Lipnik K, Ocker M, Naschberger E, Schellerer VS, Croner RS, Vieth M, Waldner M, Steinberg P, Hohenadl C, Stürzl M. Britzen-Laurent N, et al. Carcinogenesis. 2013 Jan;34(1):153-62. doi: 10.1093/carcin/bgs310. Epub 2012 Oct 6. Carcinogenesis. 2013. PMID: 23042300
IFN-γ-driven intratumoral microenvironment exhibits superior prognostic effect compared with an IFN-α-driven microenvironment in patients with colon carcinoma.
Grenz S, Naschberger E, Merkel S, Britzen-Laurent N, Schaal U, Konrad A, Aigner M, Rau TT, Hartmann A, Croner RS, Hohenberger W, Stürzl M. Grenz S, et al. Am J Pathol. 2013 Dec;183(6):1897-1909. doi: 10.1016/j.ajpath.2013.08.025. Epub 2013 Oct 8. Am J Pathol. 2013. PMID: 24121019 Free article. Clinical Trial.
Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma.
Naschberger E, Liebl A, Schellerer VS, Schütz M, Britzen-Laurent N, Kölbel P, Schaal U, Haep L, Regensburger D, Wittmann T, Klein-Hitpass L, Rau TT, Dietel B, Méniel VS, Clarke AR, Merkel S, Croner RS, Hohenberger W, Stürzl M. Naschberger E, et al. J Clin Invest. 2016 Nov 1;126(11):4187-4204. doi: 10.1172/JCI78260. Epub 2016 Oct 10. J Clin Invest. 2016. PMID: 27721236 Free PMC article.
37 results