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Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids.
Bossuat M, Rullière P, Preuilh N, Peixoto A, Joly E, Gomez JG, Bourkhis M, Rodriguez F, Gonçalves F, Fabing I, Gaspard H, Bernardes-Génisson V, Maraval V, Ballereau S, Chauvin R, Britton S, Génisson Y. Bossuat M, et al. Among authors: britton s. J Med Chem. 2023 Oct 26;66(20):13918-13945. doi: 10.1021/acs.jmedchem.3c00859. Epub 2023 Oct 10. J Med Chem. 2023. PMID: 37816126
SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species.
Demange P, Joly E, Marcoux J, Zanon PRA, Listunov D, Rullière P, Barthes C, Noirot C, Izquierdo JB, Rozié A, Pradines K, Hee R, de Brito MV, Marcellin M, Serre RF, Bouchez O, Burlet-Schiltz O, Oliveira MCF, Ballereau S, Bernardes-Génisson V, Maraval V, Calsou P, Hacker SM, Génisson Y, Chauvin R, Britton S. Demange P, et al. Among authors: britton s. Elife. 2022 May 10;11:e73913. doi: 10.7554/eLife.73913. Elife. 2022. PMID: 35535493 Free PMC article.
Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays.
Duskova K, Lamarche J, Amor S, Caron C, Queyriaux N, Gaschard M, Penouilh MJ, de Robillard G, Delmas D, Devillers CH, Granzhan A, Teulade-Fichou MP, Chavarot-Kerlidou M, Therrien B, Britton S, Monchaud D. Duskova K, et al. Among authors: britton s. J Med Chem. 2019 May 9;62(9):4456-4466. doi: 10.1021/acs.jmedchem.8b01978. Epub 2019 Apr 17. J Med Chem. 2019. PMID: 30942581
Identification of the main barriers to Ku accumulation in chromatin.
Bossaert M, Moreno A, Peixoto A, Pillaire MJ, Chanut P, Frit P, Calsou P, Loparo JJ, Britton S. Bossaert M, et al. Among authors: britton s. bioRxiv [Preprint]. 2024 Jan 4:2024.01.03.574002. doi: 10.1101/2024.01.03.574002. bioRxiv. 2024. PMID: 38260538 Free PMC article. Preprint.
DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.
Pinto LM, Pailas A, Bondarchenko M, Sharma AB, Neumann K, Rizzo AJ, Jeanty C, Nicot N, Racca C, Graham MK, Naughton C, Liu Y, Chen CL, Meakin PJ, Gilbert N, Britton S, Meeker AK, Heaphy CM, Larminat F, Van Dyck E. Pinto LM, et al. Among authors: britton s. Nucleic Acids Res. 2024 Feb 9;52(3):1136-1155. doi: 10.1093/nar/gkad1141. Nucleic Acids Res. 2024. PMID: 38038252 Free PMC article.
607 results