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A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development.
Bazzone A, Barthmes M, George C, Brinkwirth N, Zerlotti R, Prinz V, Cole K, Friis S, Dickson A, Rice S, Lim J, Fern Toh M, Mohammadi M, Pau D, Stone DJ, Renger JJ, Fertig N. Bazzone A, et al. Among authors: brinkwirth n. Int J Mol Sci. 2023 Aug 14;24(16):12788. doi: 10.3390/ijms241612788. Int J Mol Sci. 2023. PMID: 37628970 Free PMC article.
Ant venoms contain vertebrate-selective pain-causing sodium channel toxins.
Robinson SD, Deuis JR, Touchard A, Keramidas A, Mueller A, Schroeder CI, Barassé V, Walker AA, Brinkwirth N, Jami S, Bonnafé E, Treilhou M, Undheim EAB, Schmidt JO, King GF, Vetter I. Robinson SD, et al. Among authors: brinkwirth n. Nat Commun. 2023 May 23;14(1):2977. doi: 10.1038/s41467-023-38839-1. Nat Commun. 2023. PMID: 37221205 Free PMC article.
There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments.
Rapedius M, Obergrussberger A, Humphries ESA, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Liutkute A, Seibertz F, Voigt N, Fertig N. Rapedius M, et al. Among authors: brinkwirth n. Front Mol Neurosci. 2022 Aug 22;15:982316. doi: 10.3389/fnmol.2022.982316. eCollection 2022. Front Mol Neurosci. 2022. PMID: 36072300 Free PMC article.
The suitability of high throughput automated patch clamp for physiological applications.
Obergrussberger A, Rinke-Weiß I, Goetze TA, Rapedius M, Brinkwirth N, Becker N, Rotordam MG, Hutchison L, Madau P, Pau D, Dalrymple D, Braun N, Friis S, Pless SA, Fertig N. Obergrussberger A, et al. Among authors: brinkwirth n. J Physiol. 2022 Jan;600(2):277-297. doi: 10.1113/JP282107. Epub 2021 Oct 8. J Physiol. 2022. PMID: 34555195 Free article.
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment.
Rotordam MG, Obergrussberger A, Brinkwirth N, Takasuna K, Becker N, Horváth A, Goetze TA, Rapedius M, Furukawa H, Hasegawa Y, Oka T, Fertig N, Stoelzle-Feix S. Rotordam MG, et al. Among authors: brinkwirth n. J Pharmacol Toxicol Methods. 2021 Nov-Dec;112:107125. doi: 10.1016/j.vascn.2021.107125. Epub 2021 Sep 6. J Pharmacol Toxicol Methods. 2021. PMID: 34500078
Publisher Correction: Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
Kramer J, Himmel HM, Lindqvist A, Stoelzle-Feix S, Chaudhary KW, Li D, Bohme GA, Bridgland-Taylor M, Hebeisen S, Fan J, Renganathan M, Imredy J, Humphries ESA, Brinkwirth N, Strassmaier T, Ohtsuki A, Danker T, Vanoye C, Polonchuk L, Fermini B, Pierson JB, Gintant G. Kramer J, et al. Among authors: brinkwirth n. Sci Rep. 2020 Jul 14;10(1):11884. doi: 10.1038/s41598-020-68819-0. Sci Rep. 2020. PMID: 32665705 Free PMC article.
A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model.
Han X, Samieegohar M, Ridder BJ, Wu WW, Randolph A, Tran P, Sheng J, Stoelzle-Feix S, Brinkwirth N, Rotordam MG, Becker N, Friis S, Rapedius M, Goetze TA, Strassmaier T, Okeyo G, Kramer J, Kuryshev Y, Wu C, Strauss DG, Li Z. Han X, et al. Among authors: brinkwirth n. J Pharmacol Toxicol Methods. 2020 Sep;105:106890. doi: 10.1016/j.vascn.2020.106890. Epub 2020 Jun 21. J Pharmacol Toxicol Methods. 2020. PMID: 32574700 Free article.
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment.
Brinkwirth N, Takasuna K, Doi M, Becker N, Obergrussberger A, Friis S, Furukawa H, Hasegawa Y, Oka T, Ohtsuki A, Fertig N, Stoelzle-Feix S. Brinkwirth N, et al. J Pharmacol Toxicol Methods. 2020 Sep;105:106884. doi: 10.1016/j.vascn.2020.106884. Epub 2020 Jun 18. J Pharmacol Toxicol Methods. 2020. PMID: 32565325
Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961].
Ridder BJ, Leishman DJ, Bridgland-Taylor M, Samieegohar M, Han X, Wu WW, Randolph A, Tran P, Sheng J, Danker T, Lindqvist A, Konrad D, Hebeisen S, Polonchuk L, Gissinger E, Renganathan M, Koci B, Wei H, Fan J, Levesque P, Kwagh J, Imredy J, Zhai J, Rogers M, Humphries E, Kirby R, Stoelzle-Feix S, Brinkwirth N, Rotordam MG, Becker N, Friis S, Rapedius M, Goetze TA, Strassmaier T, Okeyo G, Kramer J, Kuryshev Y, Wu C, Himmel H, Mirams GR, Strauss DG, Bardenet R, Li Z. Ridder BJ, et al. Among authors: brinkwirth n. Toxicol Appl Pharmacol. 2020 May 15;395:114983. doi: 10.1016/j.taap.2020.114983. Epub 2020 Apr 2. Toxicol Appl Pharmacol. 2020. PMID: 32247767 Free PMC article. No abstract available.
13 results