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Page 1
IgG Fab Glycans Hinder FcRn-Mediated Placental Transport.
Volkov M, Brinkhaus M, van Schie KA, Bondt A, Kissel T, van der Kooi EJ, Bentlage AEH, Koeleman CAM, de Taeye SW, Derksen NI, Dolhain RJEM, Braig-Scherer U, Huizinga TWJ, Wuhrer M, Toes REM, Vidarsson G, van der Woude D. Volkov M, et al. Among authors: brinkhaus m. J Immunol. 2023 Jan 15;210(2):158-167. doi: 10.4049/jimmunol.2200438. J Immunol. 2023. PMID: 36480251
Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge.
Stapleton NM, Brinkhaus M, Armour KL, Bentlage AEH, de Taeye SW, Temming AR, Mok JY, Brasser G, Maas M, van Esch WJE, Clark MR, Williamson LM, van der Schoot CE, Vidarsson G. Stapleton NM, et al. Among authors: brinkhaus m. Sci Rep. 2019 May 14;9(1):7363. doi: 10.1038/s41598-019-40731-2. Sci Rep. 2019. PMID: 31089170 Free PMC article.
Human IgE does not bind to human FcRn.
Brinkhaus M, van der Kooi EJ, Bentlage AEH, Ooijevaar-de Heer P, Derksen NIL, Rispens T, Vidarsson G. Brinkhaus M, et al. Sci Rep. 2022 Jan 7;12(1):62. doi: 10.1038/s41598-021-03852-1. Sci Rep. 2022. PMID: 34996950 Free PMC article.
The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
Brinkhaus M, Pannecoucke E, van der Kooi EJ, Bentlage AEH, Derksen NIL, Andries J, Balbino B, Sips M, Ulrichts P, Verheesen P, de Haard H, Rispens T, Savvides SN, Vidarsson G. Brinkhaus M, et al. Nat Commun. 2022 Oct 14;13(1):6073. doi: 10.1038/s41467-022-33764-1. Nat Commun. 2022. PMID: 36241613 Free PMC article.
Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity.
Larsen MD, de Graaf EL, Sonneveld ME, Plomp HR, Nouta J, Hoepel W, Chen HJ, Linty F, Visser R, Brinkhaus M, Šuštić T, de Taeye SW, Bentlage AEH, Toivonen S, Koeleman CAM, Sainio S, Kootstra NA, Brouwer PJM, Geyer CE, Derksen NIL, Wolbink G, de Winther M, Sanders RW, van Gils MJ, de Bruin S, Vlaar APJ; Amsterdam UMC COVID-19; biobank study group; Rispens T, den Dunnen J, Zaaijer HL, Wuhrer M, Ellen van der Schoot C, Vidarsson G. Larsen MD, et al. Among authors: brinkhaus m. Science. 2021 Feb 26;371(6532):eabc8378. doi: 10.1126/science.abc8378. Epub 2020 Dec 23. Science. 2021. PMID: 33361116 Free PMC article.
Sodium stibogluconate and CD47-SIRPα blockade overcome resistance of anti-CD20-opsonized B cells to neutrophil killing.
van Rees DJ, Brinkhaus M, Klein B, Verkuijlen P, Tool ATJ, Schornagel K, Treffers LW, van Houdt M, Kater AP, Vidarsson G, Gennery AR, Kuijpers TW, van Bruggen R, Matlung HL, van den Berg TK. van Rees DJ, et al. Among authors: brinkhaus m. Blood Adv. 2022 Apr 12;6(7):2156-2166. doi: 10.1182/bloodadvances.2021005367. Blood Adv. 2022. PMID: 34942000 Free PMC article.
Impact of structural modifications of IgG antibodies on effector functions.
Damelang T, Brinkhaus M, van Osch TLJ, Schuurman J, Labrijn AF, Rispens T, Vidarsson G. Damelang T, et al. Among authors: brinkhaus m. Front Immunol. 2024 Jan 8;14:1304365. doi: 10.3389/fimmu.2023.1304365. eCollection 2023. Front Immunol. 2024. PMID: 38259472 Free PMC article. Review.
20 results