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Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex.
Weir SJ, Dandawate P, Standing D, Bhattacharyya S, Ramamoorthy P, Rangarajan P, Wood R, Brinker AE, Woolbright BL, Tanol M, Ham T, McCulloch W, Dalton M, Reed GA, Baltezor MJ, Jensen RA, Taylor JA 3rd, Anant S. Weir SJ, et al. Among authors: brinker ae. Cell Death Dis. 2021 May 31;12(6):562. doi: 10.1038/s41419-021-03836-z. Cell Death Dis. 2021. PMID: 34059639 Free PMC article.
Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs.
Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd. Weir SJ, et al. Among authors: brinker ae. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159. doi: 10.1124/jpet.119.257972. Epub 2019 May 21. J Pharmacol Exp Ther. 2019. PMID: 31113837 Free PMC article.