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Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.
Zetterberg FR, MacKinnon A, Brimert T, Gravelle L, Johnsson RE, Kahl-Knutson B, Leffler H, Nilsson UJ, Pedersen A, Peterson K, Roper JA, Schambye H, Slack RJ, Tantawi S. Zetterberg FR, et al. Among authors: brimert t. J Med Chem. 2022 Oct 13;65(19):12626-12638. doi: 10.1021/acs.jmedchem.2c00660. Epub 2022 Sep 26. J Med Chem. 2022. PMID: 36154172 Free PMC article.
An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins.
Mannerstedt K, Mishra NK, Engholm E, Lundh M, Madsen CS, Pedersen PJ, Le-Huu P, Pedersen SL, Buch-Månson N, Borgström B, Brimert T, Fink LN, Fosgerau K, Vrang N, Jensen KJ. Mannerstedt K, et al. Among authors: brimert t. Chemistry. 2021 Feb 10;27(9):3166-3176. doi: 10.1002/chem.202004878. Epub 2021 Jan 15. Chemistry. 2021. PMID: 33169429
Pyrrolo-annelated tetrathiafulvalenes: the parent systems.
Jeppesen JO, Takimiya K, Jensen F, Brimert T, Nielsen K, Thorup N, Becher J. Jeppesen JO, et al. Among authors: brimert t. J Org Chem. 2000 Sep 8;65(18):5794-805. doi: 10.1021/jo000742a. J Org Chem. 2000. PMID: 10970326
Tetrathiafulvaleno-Annelated Porphyrins.
Becher J, Brimert T, Jeppesen JO, Pedersen JZ, Zubarev R, Bjørnholm T, Reitzel N, Jensen TR, Kjaer K, Levillain E. Becher J, et al. Among authors: brimert t. Angew Chem Int Ed Engl. 2001 Jul 2;40(13):2497-2500. doi: 10.1002/1521-3773(20010702)40:13<2497::AID-ANIE2497>3.0.CO;2-F. Angew Chem Int Ed Engl. 2001. PMID: 29712278
Tetrathiafulvaleno-Annelated Porphyrins We gratefully acknowledge financial support from Carlsbergfondet and Bengt Lundquists Minnesfond for a post-doctoral position to T. B., the University of Odense for a Ph.D. scholarship to J. O. J. and the French Embassy Copenhagen for a travel grant to J. B. We thank HASYLAB at DESY, Hamburg for beam time at beam line BW1 and DANSYNC for financial support. The gift of Jan Skov Peterson's FORTRAN program LSQREFL is gratefully acknowledged. Finally, we thank Prof. K. S. Murray, University of Monash, Australia for helpful discussions.
Becher J, Brimert T, Jeppesen JO, Pedersen JZ, Zubarev R, Bjørnholm T, Reitzel N, Jensen TR, Kjaer K, Levillain E. Becher J, et al. Among authors: brimert t. Angew Chem Int Ed Engl. 2001 Jul 2;40(13):2497-2500. Angew Chem Int Ed Engl. 2001. PMID: 11443677 No abstract available.