Bright SA - Search Results

1

Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells.

Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC. Cloonan SM, et al. Among authors: bright sa. J Med Chem. 2015 Jun 11;58(11):4494-505. doi: 10.1021/acs.jmedchem.5b00451. Epub 2015 May 27. J Med Chem. 2015. PMID: 25961430

2

The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.

Bright SA, Greene LM, Greene TF, Campiani G, Butini S, Brindisi M, Lawler M, Meegan MJ, Williams DC, Zisterer DM. Bright SA, et al. Biochem Pharmacol. 2009 Feb 1;77(3):310-21. doi: 10.1016/j.bcp.2008.10.008. Epub 2008 Oct 30. Biochem Pharmacol. 2009. PMID: 19014913

3

Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.

Bright SA, Campiani G, Deininger MW, Lawler M, Williams DC, Zisterer DM. Bright SA, et al. Biochem Pharmacol. 2010 Jul 1;80(1):31-8. doi: 10.1016/j.bcp.2010.02.019. Epub 2010 Mar 3. Biochem Pharmacol. 2010. PMID: 20206141

4

Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo.

Bright SA, McElligott AM, O'Connell JW, O'Connor L, Carroll P, Campiani G, Deininger MW, Conneally E, Lawler M, Williams DC, Zisterer DM. Bright SA, et al. Br J Cancer. 2010 May 11;102(10):1474-82. doi: 10.1038/sj.bjc.6605670. Epub 2010 Apr 20. Br J Cancer. 2010. PMID: 20407438 Free PMC article.

5

Photophysical and biological investigation of novel luminescent Ru(II)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents.

Elmes RB, Erby M, Bright SA, Williams DC, Gunnlaugsson T. Elmes RB, et al. Among authors: bright sa. Chem Commun (Camb). 2012 Mar 7;48(20):2588-90. doi: 10.1039/c2cc17274g. Epub 2012 Feb 1. Chem Commun (Camb). 2012. PMID: 22293955

6

Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma.

Bright SA, Brinkø A, Larsen MT, Sinning S, Williams DC, Jensen HH. Bright SA, et al. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1220-4. doi: 10.1016/j.bmcl.2013.01.020. Epub 2013 Jan 12. Bioorg Med Chem Lett. 2013. PMID: 23385211

7

Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.

Banerjee S, Kitchen JA, Bright SA, O'Brien JE, Williams DC, Kelly JM, Gunnlaugsson T. Banerjee S, et al. Among authors: bright sa. Chem Commun (Camb). 2013 Oct 4;49(76):8522-4. doi: 10.1039/c3cc44962a. Chem Commun (Camb). 2013. PMID: 23942760

8

Synthesis and antiproliferative action of a novel series of maprotiline analogues.

McNamara YM, Bright SA, Byrne AJ, Cloonan SM, McCabe T, Williams DC, Meegan MJ. McNamara YM, et al. Among authors: bright sa. Eur J Med Chem. 2014 Jan;71:333-53. doi: 10.1016/j.ejmech.2013.10.076. Epub 2013 Nov 9. Eur J Med Chem. 2014. PMID: 24333581

9

The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.

Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM. Lennon JC, et al. Among authors: bright sa. Biochem Pharmacol. 2014 Feb 15;87(4):611-24. doi: 10.1016/j.bcp.2013.12.017. Epub 2014 Jan 6. Biochem Pharmacol. 2014. PMID: 24406249

10

Synthesis, photophysical and cytotoxicity evaluations of DNA targeting agents based on 3-amino-1,8-naphthalimide derived Tröger's bases.

Murphy S, Bright SA, Poynton FE, McCabe T, Kitchen JA, Veale EB, Williams DC, Gunnlaugsson T. Murphy S, et al. Among authors: bright sa. Org Biomol Chem. 2014 Sep 14;12(34):6610-23. doi: 10.1039/c3ob42213e. Org Biomol Chem. 2014. PMID: 24983824

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