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Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents.
Castro J, Garcia-Caraballo S, Maddern J, Schober G, Lumsden A, Harrington A, Schmiel S, Lindstrom B, Adams J, Brierley SM. Castro J, et al. Among authors: brierley sm. Pain. 2022 Jan 1;163(1):e72-e86. doi: 10.1097/j.pain.0000000000002314. Pain. 2022. PMID: 33863856 Free PMC article.
Involvement of metabotropic glutamate 5 receptor in visceral pain.
Lindström E, Brusberg M, Hughes PA, Martin CM, Brierley SM, Phillis BD, Martinsson R, Abrahamsson C, Larsson H, Martinez V, Blackshaw AL. Lindström E, et al. Among authors: brierley sm. Pain. 2008 Jul 15;137(2):295-305. doi: 10.1016/j.pain.2007.09.008. Epub 2007 Oct 15. Pain. 2008. PMID: 17937975
A novel role for TRPM8 in visceral afferent function.
Harrington AM, Hughes PA, Martin CM, Yang J, Castro J, Isaacs NJ, Blackshaw AL, Brierley SM. Harrington AM, et al. Among authors: brierley sm. Pain. 2011 Jul;152(7):1459-1468. doi: 10.1016/j.pain.2011.01.027. Epub 2011 Apr 13. Pain. 2011. PMID: 21489690
Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes.
Hughes PA, Harrington AM, Castro J, Liebregts T, Adam B, Grasby DJ, Isaacs NJ, Maldeniya L, Martin CM, Persson J, Andrews JM, Holtmann G, Blackshaw LA, Brierley SM. Hughes PA, et al. Among authors: brierley sm. Gut. 2013 Oct;62(10):1456-65. doi: 10.1136/gutjnl-2011-301856. Epub 2012 Jul 5. Gut. 2013. PMID: 22767422
Gastric vagal afferent modulation by leptin is influenced by food intake status.
Kentish SJ, O'Donnell TA, Isaacs NJ, Young RL, Li H, Harrington AM, Brierley SM, Wittert GA, Blackshaw LA, Page AJ. Kentish SJ, et al. Among authors: brierley sm. J Physiol. 2013 Apr 1;591(7):1921-34. doi: 10.1113/jphysiol.2012.247577. Epub 2012 Dec 24. J Physiol. 2013. PMID: 23266933 Free PMC article.
Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate.
Castro J, Harrington AM, Hughes PA, Martin CM, Ge P, Shea CM, Jin H, Jacobson S, Hannig G, Mann E, Cohen MB, MacDougall JE, Lavins BJ, Kurtz CB, Silos-Santiago I, Johnston JM, Currie MG, Blackshaw LA, Brierley SM. Castro J, et al. Among authors: brierley sm. Gastroenterology. 2013 Dec;145(6):1334-46.e1-11. doi: 10.1053/j.gastro.2013.08.017. Epub 2013 Aug 16. Gastroenterology. 2013. PMID: 23958540 Free article. Clinical Trial.
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