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Risk of groundwater contamination widely underestimated because of fast flow into aquifers.
Hartmann A, Jasechko S, Gleeson T, Wada Y, Andreo B, Barberá JA, Brielmann H, Bouchaou L, Charlier JB, Darling WG, Filippini M, Garvelmann J, Goldscheider N, Kralik M, Kunstmann H, Ladouche B, Lange J, Lucianetti G, Martín JF, Mudarra M, Sánchez D, Stumpp C, Zagana E, Wagener T. Hartmann A, et al. Among authors: brielmann h. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2024492118. doi: 10.1073/pnas.2024492118. Proc Natl Acad Sci U S A. 2021. PMID: 33972438 Free PMC article.
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Blum CA, Caldwell T, Zheng X, Bakthavatchalam R, Capitosti S, Brielmann H, De Lombaert S, Kershaw MT, Matson D, Krause JE, Cortright D, Crandall M, Martin WJ, Murphy BA, Boyce S, Jones AB, Mason G, Rycroft W, Perrett H, Conley R, Burnaby-Davies N, Chenard BL, Hodgetts KJ. Blum CA, et al. Among authors: brielmann h. J Med Chem. 2010 Apr 22;53(8):3330-48. doi: 10.1021/jm100051g. J Med Chem. 2010. PMID: 20307063
Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.
Blum CA, Zheng X, Brielmann H, Hodgetts KJ, Bakthavatchalam R, Chandrasekhar J, Krause JE, Cortright D, Matson D, Crandall M, Ngo CK, Fung L, Day M, Kershaw M, De Lombaert S, Chenard BL. Blum CA, et al. Among authors: brielmann h. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4573-7. doi: 10.1016/j.bmcl.2008.07.036. Epub 2008 Jul 15. Bioorg Med Chem Lett. 2008. PMID: 18662872
From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.
Zheng X, Hodgetts KJ, Brielmann H, Hutchison A, Burkamp F, Brian Jones A, Blurton P, Clarkson R, Chandrasekhar J, Bakthavatchalam R, De Lombaert S, Crandall M, Cortright D, Blum CA. Zheng X, et al. Among authors: brielmann h. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5217-21. doi: 10.1016/j.bmcl.2006.07.010. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870426