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A flavivirus protein M-derived peptide directly permeabilizes mitochondrial membranes, triggers cell death and reduces human tumor growth in nude mice.
Brabant M, Baux L, Casimir R, Briand JP, Chaloin O, Porceddu M, Buron N, Chauvier D, Lassalle M, Lecoeur H, Langonné A, Dupont S, Déas O, Brenner C, Rebouillat D, Muller S, Borgne-Sanchez A, Jacotot E. Brabant M, et al. Among authors: briand jp. Apoptosis. 2009 Oct;14(10):1190-203. doi: 10.1007/s10495-009-0394-y. Apoptosis. 2009. PMID: 19693674
Therapeutic peptides: Targeting the mitochondrion to modulate apoptosis.
Jacotot E, Deniaud A, Borgne-Sanchez A, Touat Z, Briand JP, Le Bras M, Brenner C. Jacotot E, et al. Among authors: briand jp. Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1312-23. doi: 10.1016/j.bbabio.2006.07.002. Epub 2006 Jul 14. Biochim Biophys Acta. 2006. PMID: 16928356 Free article. Review.
A simple approach to cancer therapy afforded by multivalent pseudopeptides that target cell-surface nucleoproteins.
Destouches D, Page N, Hamma-Kourbali Y, Machi V, Chaloin O, Frechault S, Birmpas C, Katsoris P, Beyrath J, Albanese P, Maurer M, Carpentier G, Strub JM, Van Dorsselaer A, Muller S, Bagnard D, Briand JP, Courty J. Destouches D, et al. Among authors: briand jp. Cancer Res. 2011 May 1;71(9):3296-305. doi: 10.1158/0008-5472.CAN-10-3459. Epub 2011 Mar 17. Cancer Res. 2011. PMID: 21415166 Free article.
Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2.
Jacotot E, Ferri KF, El Hamel C, Brenner C, Druillennec S, Hoebeke J, Rustin P, Métivier D, Lenoir C, Geuskens M, Vieira HL, Loeffler M, Belzacq AS, Briand JP, Zamzami N, Edelman L, Xie ZH, Reed JC, Roques BP, Kroemer G. Jacotot E, et al. Among authors: briand jp. J Exp Med. 2001 Feb 19;193(4):509-19. doi: 10.1084/jem.193.4.509. J Exp Med. 2001. PMID: 11181702 Free PMC article.
263 results