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The molecular basis of transient heme-protein interactions: analysis, concept and implementation.
Biosci Rep. 2019 Jan 30;39(1):BSR20181940. doi: 10.1042/BSR20181940. Print 2019 Jan 31.
Biosci Rep. 2019.
PMID: 30622148
Free PMC article.
Review.
Structural and functional diversity of transient heme binding to bacterial proteins.
Brewitz HH, Hagelueken G, Imhof D.
Brewitz HH, et al.
Biochim Biophys Acta Gen Subj. 2017 Mar;1861(3):683-697. doi: 10.1016/j.bbagen.2016.12.021. Epub 2016 Dec 22.
Biochim Biophys Acta Gen Subj. 2017.
PMID: 28012743
Review.
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Role of the Chemical Environment beyond the Coordination Site: Structural Insight into Fe(III) Protoporphyrin Binding to Cysteine-Based Heme-Regulatory Protein Motifs.
Brewitz HH, Kühl T, Goradia N, Galler K, Popp J, Neugebauer U, Ohlenschläger O, Imhof D.
Brewitz HH, et al.
Chembiochem. 2015 Oct 12;16(15):2216-24. doi: 10.1002/cbic.201500331. Epub 2015 Sep 7.
Chembiochem. 2015.
PMID: 26260099
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Heme interacts with histidine- and tyrosine-based protein motifs and inhibits enzymatic activity of chloramphenicol acetyltransferase from Escherichia coli.
Brewitz HH, Goradia N, Schubert E, Galler K, Kühl T, Syllwasschy B, Popp J, Neugebauer U, Hagelueken G, Schiemann O, Ohlenschläger O, Imhof D.
Brewitz HH, et al.
Biochim Biophys Acta. 2016 Jun;1860(6):1343-53. doi: 10.1016/j.bbagen.2016.03.027. Epub 2016 Mar 23.
Biochim Biophys Acta. 2016.
PMID: 27015758
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Insights into mechanism and functional consequences of heme binding to hemolysin-activating lysine acyltransferase HlyC from Escherichia coli.
Peherstorfer S, Brewitz HH, Paul George AA, Wißbrock A, Adam JM, Schmitt L, Imhof D.
Peherstorfer S, et al. Among authors: brewitz hh.
Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1964-1972. doi: 10.1016/j.bbagen.2018.06.012. Epub 2018 Jun 15.
Biochim Biophys Acta Gen Subj. 2018.
PMID: 29908817
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A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.
Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E.
Schmitz AL, et al. Among authors: brewitz hh.
Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003.
Chem Biol. 2014.
PMID: 25036778
Free PMC article.
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CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2).
Gessner G, Sahoo N, Swain SM, Hirth G, Schönherr R, Mede R, Westerhausen M, Brewitz HH, Heimer P, Imhof D, Hoshi T, Heinemann SH.
Gessner G, et al. Among authors: brewitz hh.
Eur J Pharmacol. 2017 Nov 15;815:33-41. doi: 10.1016/j.ejphar.2017.10.006. Epub 2017 Oct 5.
Eur J Pharmacol. 2017.
PMID: 28987271
Free PMC article.
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