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Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
Shukla R, Lavore F, Maity S, Derks MGN, Jones CR, Vermeulen BJA, Melcrová A, Morris MA, Becker LM, Wang X, Kumar R, Medeiros-Silva J, van Beekveld RAM, Bonvin AMJJ, Lorent JH, Lelli M, Nowick JS, MacGillavry HD, Peoples AJ, Spoering AL, Ling LL, Hughes DE, Roos WH, Breukink E, Lewis K, Weingarth M. Shukla R, et al. Among authors: breukink e. Nature. 2022 Aug;608(7922):390-396. doi: 10.1038/s41586-022-05019-y. Epub 2022 Aug 3. Nature. 2022. PMID: 35922513 Free PMC article.
High-resolution NMR studies of antibiotics in cellular membranes.
Medeiros-Silva J, Jekhmane S, Paioni AL, Gawarecka K, Baldus M, Swiezewska E, Breukink E, Weingarth M. Medeiros-Silva J, et al. Among authors: breukink e. Nat Commun. 2018 Sep 27;9(1):3963. doi: 10.1038/s41467-018-06314-x. Nat Commun. 2018. PMID: 30262913 Free PMC article.
Mode of action of teixobactins in cellular membranes.
Shukla R, Medeiros-Silva J, Parmar A, Vermeulen BJA, Das S, Paioni AL, Jekhmane S, Lorent J, Bonvin AMJJ, Baldus M, Lelli M, Veldhuizen EJA, Breukink E, Singh I, Weingarth M. Shukla R, et al. Among authors: breukink e. Nat Commun. 2020 Jun 5;11(1):2848. doi: 10.1038/s41467-020-16600-2. Nat Commun. 2020. PMID: 32503964 Free PMC article.
Towards the Native Binding Modes of Antibiotics that Target Lipid II.
Medeiros-Silva J, Jekhmane S, Breukink E, Weingarth M. Medeiros-Silva J, et al. Among authors: breukink e. Chembiochem. 2019 Jul 15;20(14):1731-1738. doi: 10.1002/cbic.201800796. Epub 2019 May 22. Chembiochem. 2019. PMID: 30725496 Free PMC article. Review.
Specific Lipid Studies in Complex Membranes by Solid-State NMR Spectroscopy.
van Beekveld RAM, Derks MGN, Kumar R, Smid L, Maass T, Medeiros-Silva J, Breukink E, Weingarth M. van Beekveld RAM, et al. Among authors: breukink e. Chemistry. 2022 Dec 15;28(70):e202202472. doi: 10.1002/chem.202202472. Epub 2022 Oct 25. Chemistry. 2022. PMID: 36098094 Free PMC article.
156 results