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A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation.
Acchioni C, Acchioni M, Mancini F, Amendola A, Marsili G, Tirelli V, Gwee CP, Chan KW, Sandini S, Bisbocci M, Mysara M, ElHefnawi M, Sanchez M, Venturi G, Barreca ML, Manfroni G, Bresciani A, Vasudevan SG, Sgarbanti M. Acchioni C, et al. Among authors: bresciani a. Virology. 2023 Jun;583:1-13. doi: 10.1016/j.virol.2023.03.016. Epub 2023 Apr 5. Virology. 2023. PMID: 37060797 Free article.
Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes.
Paonessa G, Siciliano G, Graziani R, Lalli C, Cecchetti O, Alli C, La Valle R, Petrocchi A, Sferrazza A, Bisbocci M, Falchi M, Toniatti C, Bresciani A, Alano P. Paonessa G, et al. Among authors: bresciani a. Commun Biol. 2022 Jun 6;5(1):547. doi: 10.1038/s42003-022-03510-w. Commun Biol. 2022. PMID: 35668202 Free PMC article.
Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and β-globin gene promoters.
Breveglieri G, Salvatori F, Finotti A, Cosenza LC, Zuccato C, Bianchi N, Breda L, Rivella S, Bresciani A, Bisbocci M, Borgatti M, Gambari R. Breveglieri G, et al. Among authors: bresciani a. Anal Bioanal Chem. 2019 Nov;411(29):7669-7680. doi: 10.1007/s00216-019-01959-z. Epub 2019 Jul 4. Anal Bioanal Chem. 2019. PMID: 31273412
Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.
Turcano L, Torrente E, Missineo A, Andreini M, Gramiccia M, Di Muccio T, Genovese I, Fiorillo A, Harper S, Bresciani A, Colotti G, Ilari A. Turcano L, et al. Among authors: bresciani a. PLoS Negl Trop Dis. 2018 Nov 26;12(11):e0006969. doi: 10.1371/journal.pntd.0006969. eCollection 2018 Nov. PLoS Negl Trop Dis. 2018. PMID: 30475811 Free PMC article.
Identification of HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases.
Chierichetti M, Cerretani M, Ciammaichella A, Crippa V, Rusmini P, Ferrari V, Tedesco B, Casarotto E, Cozzi M, Mina F, Pramaggiore P, Galbiati M, Piccolella M, Bresciani A, Cristofani R, Poletti A. Chierichetti M, et al. Among authors: bresciani a. Life Sci. 2023 Jun 1;322:121323. doi: 10.1016/j.lfs.2022.121323. Epub 2022 Dec 24. Life Sci. 2023. PMID: 36574942 Free article.
NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model.
Moretti D, Tambone S, Cerretani M, Fezzardi P, Missineo A, Sherman LT, Munoz-Sajuan I, Harper S, Dominquez C, Pacifici R, Tomei L, Park L, Bresciani A. Moretti D, et al. Among authors: bresciani a. Free Radic Biol Med. 2021 Jan;162:243-254. doi: 10.1016/j.freeradbiomed.2020.10.022. Epub 2020 Oct 21. Free Radic Biol Med. 2021. PMID: 33096251
105 results