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Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
Nishio T, Koyama Y, Liu X, Rosenthal SB, Yamamoto G, Fuji H, Baglieri J, Li N, Brenner LN, Iwaisako K, Taura K, Hagood JS, LaRusso NF, Bera TK, Pastan I, Brenner DA, Kisseleva T. Nishio T, et al. Among authors: brenner ln, brenner da. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2101270118. doi: 10.1073/pnas.2101270118. Proc Natl Acad Sci U S A. 2021. PMID: 34253615 Free PMC article.
Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.
Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner DA, Schnabl B. Iwaisako K, et al. Among authors: brenner da. Proc Natl Acad Sci U S A. 2012 May 22;109(21):E1369-76. doi: 10.1073/pnas.1202464109. Epub 2012 Apr 25. Proc Natl Acad Sci U S A. 2012. PMID: 22538808 Free PMC article.
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis.
Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA. Kisseleva T, et al. Among authors: brenner da. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9448-53. doi: 10.1073/pnas.1201840109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566629 Free PMC article.
Origin of myofibroblasts in the fibrotic liver in mice.
Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner DA, Kisseleva T. Iwaisako K, et al. Among authors: brenner da. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3297-305. doi: 10.1073/pnas.1400062111. Epub 2014 Jul 29. Proc Natl Acad Sci U S A. 2014. PMID: 25074909 Free PMC article.
NK and NKT cells in liver injury and fibrosis.
Notas G, Kisseleva T, Brenner D. Notas G, et al. Clin Immunol. 2009 Jan;130(1):16-26. doi: 10.1016/j.clim.2008.08.008. Epub 2008 Sep 26. Clin Immunol. 2009. PMID: 18823822 Review.
453 results