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Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase.
Myeni SK, Bredenbeek PJ, Knaap RCM, Dalebout TJ, Morales ST, Sidorov IA, Linger ME, Oreshkova N, van Zanen-Gerhardt S, Zander SAL, Enjuanes L, Sola I, Snijder EJ, Kikkert M. Myeni SK, et al. Among authors: bredenbeek pj. Nat Commun. 2023 Feb 28;14(1):1141. doi: 10.1038/s41467-023-36754-z. Nat Commun. 2023. PMID: 36854765 Free PMC article.
Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.
Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL. Bailey-Elkin BA, et al. Among authors: bredenbeek pj. J Biol Chem. 2014 Dec 12;289(50):34667-82. doi: 10.1074/jbc.M114.609644. Epub 2014 Oct 15. J Biol Chem. 2014. PMID: 25320088 Free PMC article.
A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection.
Pardieck IN, van der Sluis TC, van der Gracht ETI, Veerkamp DMB, Behr FM, van Duikeren S, Beyrend G, Rip J, Nadafi R, Beyranvand Nejad E, Mülling N, Brasem DJ, Camps MGM, Myeni SK, Bredenbeek PJ, Kikkert M, Kim Y, Cicin-Sain L, Abdelaal T, van Gisbergen KPJM, Franken KLMC, Drijfhout JW, Melief CJM, Zondag GCM, Ossendorp F, Arens R. Pardieck IN, et al. Among authors: bredenbeek pj. Nat Commun. 2022 Jul 8;13(1):3966. doi: 10.1038/s41467-022-31721-6. Nat Commun. 2022. PMID: 35803932 Free PMC article.
46 results