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Drosophila eye color mutants as therapeutic tools for Huntington disease.
Green EW, Campesan S, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. Green EW, et al. Among authors: breda c. Fly (Austin). 2012 Apr-Jun;6(2):117-20. doi: 10.4161/fly.19999. Epub 2012 Apr 1. Fly (Austin). 2012. PMID: 22634544
Glycation potentiates neurodegeneration in models of Huntington's disease.
Vicente Miranda H, Gomes MA, Branco-Santos J, Breda C, Lázaro DF, Lopes LV, Herrera F, Giorgini F, Outeiro TF. Vicente Miranda H, et al. Among authors: breda c. Sci Rep. 2016 Nov 18;6:36798. doi: 10.1038/srep36798. Sci Rep. 2016. PMID: 27857176 Free PMC article.
A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.
Zhang S, Sakuma M, Deora GS, Levy CW, Klausing A, Breda C, Read KD, Edlin CD, Ross BP, Wright Muelas M, Day PJ, O'Hagan S, Kell DB, Schwarcz R, Leys D, Heyes DJ, Giorgini F, Scrutton NS. Zhang S, et al. Among authors: breda c. Commun Biol. 2019 Jul 24;2:271. doi: 10.1038/s42003-019-0520-5. eCollection 2019. Commun Biol. 2019. PMID: 31372510 Free PMC article.
A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.
Maddison DC, Alfonso-Núñez M, Swaih AM, Breda C, Campesan S, Allcock N, Straatman-Iwanowska A, Kyriacou CP, Giorgini F. Maddison DC, et al. Among authors: breda c. PLoS Genet. 2020 Nov 10;16(11):e1009129. doi: 10.1371/journal.pgen.1009129. eCollection 2020 Nov. PLoS Genet. 2020. PMID: 33170836 Free PMC article.
108 results