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Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors.
Cazanave SC, Warren AD, Pacula M, Touti F, Zagorska A, Gural N, Huang EK, Sherman S, Cheema M, Ibarra S, Bates J, Billin AN, Liles JT, Budas GR, Breckenridge DG, Tiniakos D, Ratziu V, Daly AK, Govaere O, Anstee QM, Gelrud L, Luther J, Chung RT, Corey KE, Winckler W, Bhatia S, Kwong GA. Cazanave SC, et al. Among authors: breckenridge dg. Sci Transl Med. 2021 Oct 20;13(616):eabe8939. doi: 10.1126/scitranslmed.abe8939. Epub 2021 Oct 20. Sci Transl Med. 2021. PMID: 34669440
Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation.
Bates J, Vijayakumar A, Ghoshal S, Marchand B, Yi S, Kornyeyev D, Zagorska A, Hollenback D, Walker K, Liu K, Pendem S, Newstrom D, Brockett R, Mikaelian I, Kusam S, Ramirez R, Lopez D, Li L, Fuchs BC, Breckenridge DG. Bates J, et al. Among authors: breckenridge dg. J Hepatol. 2020 Oct;73(4):896-905. doi: 10.1016/j.jhep.2020.04.037. Epub 2020 May 4. J Hepatol. 2020. PMID: 32376414 Free article.
Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis.
Vijayakumar A, Okesli-Armlovich A, Wang T, Olson I, Seung M, Kusam S, Hollenback D, Mahadevan S, Marchand B, Toteva M, Breckenridge DG, Trevaskis JL, Bates J. Vijayakumar A, et al. Among authors: breckenridge dg. Hepatol Commun. 2022 Sep;6(9):2298-2309. doi: 10.1002/hep4.2011. Epub 2022 Jun 23. Hepatol Commun. 2022. PMID: 35735253 Free PMC article.
Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis.
Dobie R, Wilson-Kanamori JR, Henderson BEP, Smith JR, Matchett KP, Portman JR, Wallenborg K, Picelli S, Zagorska A, Pendem SV, Hudson TE, Wu MM, Budas GR, Breckenridge DG, Harrison EM, Mole DJ, Wigmore SJ, Ramachandran P, Ponting CP, Teichmann SA, Marioni JC, Henderson NC. Dobie R, et al. Among authors: breckenridge dg. Cell Rep. 2019 Nov 12;29(7):1832-1847.e8. doi: 10.1016/j.celrep.2019.10.024. Cell Rep. 2019. PMID: 31722201 Free PMC article.
ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
Liles JT, Corkey BK, Notte GT, Budas GR, Lansdon EB, Hinojosa-Kirschenbaum F, Badal SS, Lee M, Schultz BE, Wise S, Pendem S, Graupe M, Castonguay L, Koch KA, Wong MH, Papalia GA, French DM, Sullivan T, Huntzicker EG, Ma FY, Nikolic-Paterson DJ, Altuhaifi T, Yang H, Fogo AB, Breckenridge DG. Liles JT, et al. Among authors: breckenridge dg. J Clin Invest. 2018 Oct 1;128(10):4485-4500. doi: 10.1172/JCI99768. Epub 2018 Jul 19. J Clin Invest. 2018. PMID: 30024858 Free PMC article.
The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model.
Schwabl P, Hambruch E, Budas GR, Supper P, Burnet M, Liles JT, Birkel M, Brusilovskaya K, Königshofer P, Peck-Radosavljevic M, Watkins WJ, Trauner M, Breckenridge DG, Kremoser C, Reiberger T. Schwabl P, et al. Among authors: breckenridge dg. Biomedicines. 2021 Jan 9;9(1):60. doi: 10.3390/biomedicines9010060. Biomedicines. 2021. PMID: 33435509 Free PMC article.
28 results