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Regulatory Experiences with Root Causes and Risk Factors for Nitrosamine Impurities in Pharmaceuticals.
J Pharm Sci. 2023 May;112(5):1166-1182. doi: 10.1016/j.xphs.2022.12.022. Epub 2023 Jan 1.
J Pharm Sci. 2023.
PMID: 36599405
International Regulatory Collaboration on the Analysis of Nitrosamines in Metformin-Containing Medicines.
Keire DA, Bream R, Wollein U, Schmaler-Ripcke J, Burchardt A, Conti M, Zmysłowski A, Keizers P, Morin J, Poh J, George M, Wierer M.
Keire DA, et al.
AAPS J. 2022 Apr 21;24(3):56. doi: 10.1208/s12248-022-00702-4.
AAPS J. 2022.
PMID: 35449372
Review.
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Correction: International Regulatory Collaboration on the Analysis of Nitrosamines in Metformin-Containing Medicines.
Keire DA, Bream R, Wollein U, Schmaler-Ripcke, Burchardt A, Conti M, Zmysłowski A, Keizers P, Morin J, Poh J, George M, Wierer M.
Keire DA, et al.
AAPS J. 2022 Jul 13;24(4):84. doi: 10.1208/s12248-022-00734-w.
AAPS J. 2022.
PMID: 35831631
No abstract available.
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The EU Response to the Presence of Nitrosamine Impurities in Medicines.
Ruepp R, Frötschl R, Bream R, Filancia M, Girard T, Spinei A, Weise M, Whomsley R.
Ruepp R, et al.
Front Med (Lausanne). 2021 Nov 19;8:782536. doi: 10.3389/fmed.2021.782536. eCollection 2021.
Front Med (Lausanne). 2021.
PMID: 34869504
Free PMC article.
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Design and Application of a DNA-Encoded Macrocyclic Peptide Library.
Zhu Z, Shaginian A, Grady LC, O'Keeffe T, Shi XE, Davie CP, Simpson GL, Messer JA, Evindar G, Bream RN, Thansandote PP, Prentice NR, Mason AM, Pal S.
Zhu Z, et al. Among authors: bream rn.
ACS Chem Biol. 2018 Jan 19;13(1):53-59. doi: 10.1021/acschembio.7b00852. Epub 2017 Dec 4.
ACS Chem Biol. 2018.
PMID: 29185700
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Radical-mediated reduction of the dithiocarbamate group under tin-free conditions.
McMaster C, Bream RN, Grainger RS.
McMaster C, et al. Among authors: bream rn.
Org Biomol Chem. 2012 Jun 28;10(24):4752-8. doi: 10.1039/c2ob25434d. Epub 2012 May 15.
Org Biomol Chem. 2012.
PMID: 22588594
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Asymmetric allylic alkylation of cyclic vinylogous esters and thioesters by Pd-catalyzed decarboxylation of enol carbonate and beta-ketoester substrates.
Trost BM, Bream RN, Xu J.
Trost BM, et al. Among authors: bream rn.
Angew Chem Int Ed Engl. 2006 May 5;45(19):3109-12. doi: 10.1002/anie.200504421.
Angew Chem Int Ed Engl. 2006.
PMID: 16596689
No abstract available.
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Synthesis of the beta 2 agonist (R)-salmeterol using a sequence of supported reagents and scavenging agents.
Bream RN, Ley SV, Procopiou PA.
Bream RN, et al.
Org Lett. 2002 Oct 31;4(22):3793-6. doi: 10.1021/ol020128g.
Org Lett. 2002.
PMID: 12599460
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