Brayer GD - Search Results

1

Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase.

Tysoe CR, Caner S, Calvert MB, Win-Mason A, Brayer GD, Withers SG. Tysoe CR, et al. Among authors: brayer gd. Chem Sci. 2019 Oct 18;10(48):11073-11077. doi: 10.1039/c9sc02610j. eCollection 2019 Dec 28. Chem Sci. 2019. PMID: 32206255 Free PMC article.

2

The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif.

Williams LK, Zhang X, Caner S, Tysoe C, Nguyen NT, Wicki J, Williams DE, Coleman J, McNeill JH, Yuen V, Andersen RJ, Withers SG, Brayer GD. Williams LK, et al. Among authors: brayer gd. Nat Chem Biol. 2015 Sep;11(9):691-6. doi: 10.1038/nchembio.1865. Epub 2015 Jul 27. Nat Chem Biol. 2015. PMID: 26214255

3

Potent Human α-Amylase Inhibition by the β-Defensin-like Protein Helianthamide.

Tysoe C, Williams LK, Keyzers R, Nguyen NT, Tarling C, Wicki J, Goddard-Borger ED, Aguda AH, Perry S, Foster LJ, Andersen RJ, Brayer GD, Withers SG. Tysoe C, et al. Among authors: brayer gd. ACS Cent Sci. 2016 Mar 23;2(3):154-161. doi: 10.1021/acscentsci.5b00399. Epub 2016 Feb 26. ACS Cent Sci. 2016. PMID: 27066537 Free PMC article.

4

Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides.

Jongkees SAK, Caner S, Tysoe C, Brayer GD, Withers SG, Suga H. Jongkees SAK, et al. Among authors: brayer gd. Cell Chem Biol. 2017 Mar 16;24(3):381-390. doi: 10.1016/j.chembiol.2017.02.001. Epub 2017 Mar 2. Cell Chem Biol. 2017. PMID: 28262556 Free article.

5

Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.

Numao S, Maurus R, Sidhu G, Wang Y, Overall CM, Brayer GD, Withers SG. Numao S, et al. Among authors: brayer gd. Biochemistry. 2002 Jan 8;41(1):215-25. doi: 10.1021/bi0115636. Biochemistry. 2002. PMID: 11772019

6

Synthesis and characterisation of novel chromogenic substrates for human pancreatic alpha-amylase.

Damager I, Numao S, Chen H, Brayer GD, Withers SG. Damager I, et al. Among authors: brayer gd. Carbohydr Res. 2004 Jul 12;339(10):1727-37. doi: 10.1016/j.carres.2004.05.019. Carbohydr Res. 2004. PMID: 15220082

7

Acarbose rearrangement mechanism implied by the kinetic and structural analysis of human pancreatic alpha-amylase in complex with analogues and their elongated counterparts.

Li C, Begum A, Numao S, Park KH, Withers SG, Brayer GD. Li C, et al. Among authors: brayer gd. Biochemistry. 2005 Mar 8;44(9):3347-57. doi: 10.1021/bi048334e. Biochemistry. 2005. PMID: 15736945

8

The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts.

Tarling CA, Woods K, Zhang R, Brastianos HC, Brayer GD, Andersen RJ, Withers SG. Tarling CA, et al. Among authors: brayer gd. Chembiochem. 2008 Feb 15;9(3):433-8. doi: 10.1002/cbic.200700470. Chembiochem. 2008. PMID: 18214874

9

Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase.

Zhang R, Li C, Williams LK, Rempel BP, Brayer GD, Withers SG. Zhang R, et al. Among authors: brayer gd. Biochemistry. 2009 Nov 17;48(45):10752-64. doi: 10.1021/bi901400p. Biochemistry. 2009. PMID: 19803533

10

Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.

Williams LK, Li C, Withers SG, Brayer GD. Williams LK, et al. Among authors: brayer gd. J Med Chem. 2012 Nov 26;55(22):10177-86. doi: 10.1021/jm301273u. Epub 2012 Oct 24. J Med Chem. 2012. PMID: 23050660

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