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The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.
Yakhine-Diop SMS, Rodríguez-Arribas M, Canales-Cortés S, Martínez-Chacón G, Uribe-Carretero E, Blanco-Benítez M, Duque-González G, Paredes-Barquero M, Alegre-Cortés E, Climent V, Aiastui A, López de Munain A, Bravo-San Pedro JM, Niso-Santano M, Fuentes JM, González-Polo RA. Yakhine-Diop SMS, et al. Cell Biol Toxicol. 2022 Oct;38(5):889-911. doi: 10.1007/s10565-021-09617-w. Epub 2021 May 31. Cell Biol Toxicol. 2022. PMID: 34060004
The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.
Bravo-San Pedro JM, Niso-Santano M, Gómez-Sánchez R, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. Bravo-San Pedro JM, et al. Cell Mol Life Sci. 2013 Jan;70(1):121-36. doi: 10.1007/s00018-012-1061-y. Epub 2012 Jul 8. Cell Mol Life Sci. 2013. PMID: 22773119
The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts.
Bravo-San Pedro JM, Gómez-Sánchez R, Niso-Santano M, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. Bravo-San Pedro JM, et al. Autophagy. 2012 Oct;8(10):1537-9. doi: 10.4161/auto.21270. Epub 2012 Aug 23. Autophagy. 2012. PMID: 22914360 Free PMC article.
G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.
Yakhine-Diop SM, Bravo-San Pedro JM, Gómez-Sánchez R, Pizarro-Estrella E, Rodríguez-Arribas M, Climent V, Aiastui A, López de Munain A, Fuentes JM, González-Polo RA. Yakhine-Diop SM, et al. Toxicology. 2014 Oct 3;324:1-9. doi: 10.1016/j.tox.2014.07.001. Epub 2014 Jul 10. Toxicology. 2014. PMID: 25017139
ER-mitochondria signaling in Parkinson's disease.
Gómez-Suaga P, Bravo-San Pedro JM, González-Polo RA, Fuentes JM, Niso-Santano M. Gómez-Suaga P, et al. Cell Death Dis. 2018 Mar 1;9(3):337. doi: 10.1038/s41419-017-0079-3. Cell Death Dis. 2018. PMID: 29497039 Free PMC article. Review.
Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients.
Yakhine-Diop SMS, Niso-Santano M, Rodríguez-Arribas M, Gómez-Sánchez R, Martínez-Chacón G, Uribe-Carretero E, Navarro-García JA, Ruiz-Hurtado G, Aiastui A, Cooper JM, López de Munaín A, Bravo-San Pedro JM, González-Polo RA, Fuentes JM. Yakhine-Diop SMS, et al. Mol Neurobiol. 2019 Apr;56(4):2466-2481. doi: 10.1007/s12035-018-1206-6. Epub 2018 Jul 21. Mol Neurobiol. 2019. PMID: 30032424
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.
Niso-Santano M, González-Polo RA, Bravo-San Pedro JM, Gómez-Sánchez R, Lastres-Becker I, Ortiz-Ortiz MA, Soler G, Morán JM, Cuadrado A, Fuentes JM; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED). Niso-Santano M, et al. Free Radic Biol Med. 2010 May 15;48(10):1370-81. doi: 10.1016/j.freeradbiomed.2010.02.024. Epub 2010 Mar 2. Free Radic Biol Med. 2010. PMID: 20202476
104 results