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Page 1
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression.
Juárez-Fernández M, Goikoetxea-Usandizaga N, Porras D, García-Mediavilla MV, Bravo M, Serrano-Maciá M, Simón J, Delgado TC, Lachiondo-Ortega S, Martínez-Flórez S, Lorenzo Ó, Rincón M, Varela-Rey M, Abecia L, Rodríguez H, Anguita J, Nistal E, Martínez-Chantar ML, Sánchez-Campos S. Juárez-Fernández M, et al. Among authors: bravo m. Hepatology. 2023 May 1;77(5):1654-1669. doi: 10.1002/hep.32705. Epub 2023 Apr 17. Hepatology. 2023. PMID: 35921199 Free PMC article.
Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury.
Iruzubieta P, Goikoetxea-Usandizaga N, Barbier-Torres L, Serrano-Maciá M, Fernández-Ramos D, Fernández-Tussy P, Gutiérrez-de-Juan V, Lachiondo-Ortega S, Simon J, Bravo M, Lopitz-Otsoa F, Robles M, Ferre-Aracil C, Varela-Rey M, Elguezabal N, Calleja JL, Lu SC, Milkiewicz M, Milkiewicz P, Anguita J, Monte MJ, Marin JJG, López-Hoyos M, Delgado TC, Rincón M, Crespo J, Martínez-Chantar ML. Iruzubieta P, et al. Among authors: bravo m. JHEP Rep. 2021 Mar 18;3(3):100276. doi: 10.1016/j.jhepr.2021.100276. eCollection 2021 Jun. JHEP Rep. 2021. PMID: 33997750 Free PMC article.
Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals.
Goikoetxea-Usandizaga N, Serrano-Maciá M, Delgado TC, Simón J, Fernández Ramos D, Barriales D, Cornide ME, Jiménez M, Pérez-Redondo M, Lachiondo-Ortega S, Rodríguez-Agudo R, Bizkarguenaga M, Zalamea JD, Pasco ST, Caballero-Díaz D, Alfano B, Bravo M, González-Recio I, Mercado-Gómez M, Gil-Pitarch C, Mabe J, Gracia-Sancho J, Abecia L, Lorenzo Ó, Martín-Sanz P, Abrescia NGA, Sabio G, Rincón M, Anguita J, Miñambres E, Martín C, Berenguer M, Fabregat I, Casado M, Peralta C, Varela-Rey M, Martínez-Chantar ML. Goikoetxea-Usandizaga N, et al. Among authors: bravo m. Hepatology. 2022 Mar;75(3):550-566. doi: 10.1002/hep.32149. Epub 2021 Dec 15. Hepatology. 2022. PMID: 34510498 Free PMC article.
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.
Rodríguez-Agudo R, Goikoetxea-Usandizaga N, Serrano-Maciá M, Fernández-Tussy P, Fernández-Ramos D, Lachiondo-Ortega S, González-Recio I, Gil-Pitarch C, Mercado-Gómez M, Morán L, Bizkarguenaga M, Lopitz-Otsoa F, Petrov P, Bravo M, Van Liempd SM, Falcon-Perez JM, Zabala-Letona A, Carracedo A, Castell JV, Jover R, Martínez-Cruz LA, Delgado TC, Cubero FJ, Lucena MI, Andrade RJ, Mabe J, Simón J, Martínez-Chantar ML. Rodríguez-Agudo R, et al. Among authors: bravo m. Antioxidants (Basel). 2022 Apr 30;11(5):897. doi: 10.3390/antiox11050897. Antioxidants (Basel). 2022. PMID: 35624761 Free PMC article.
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes.
Mercado-Gómez M, Prieto-Fernández E, Goikoetxea-Usandizaga N, Vila-Vecilla L, Azkargorta M, Bravo M, Serrano-Maciá M, Egia-Mendikute L, Rodríguez-Agudo R, Lachiondo-Ortega S, Lee SY, Eguileor Giné A, Gil-Pitarch C, González-Recio I, Simón J, Petrov P, Jover R, Martínez-Cruz LA, Ereño-Orbea J, Delgado TC, Elortza F, Jiménez-Barbero J, Nogueiras R, Prevot V, Palazon A, Martínez-Chantar ML. Mercado-Gómez M, et al. Among authors: bravo m. Commun Biol. 2022 Aug 17;5(1):827. doi: 10.1038/s42003-022-03789-9. Commun Biol. 2022. PMID: 35978143 Free PMC article.
The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent.
Goikoetxea-Usandizaga N, Bravo M, Egia-Mendikute L, Abecia L, Serrano-Maciá M, Urdinguio RG, Clos-García M, Rodríguez-Agudo R, Araujo-Legido R, López-Bermudo L, Delgado TC, Lachiondo-Ortega S, González-Recio I, Gil-Pitarch C, Peña-Cearra A, Simón J, Benedé-Ubieto R, Ariño S, Herranz JM, Azkargorta M, Salazar-Bermeo J, Martí N, Varela-Rey M, Falcón-Pérez JM, Lorenzo Ó, Nogueiras R, Elortza F, Nevzorova YA, Cubero FJ, Saura D, Martínez-Cruz LA, Sabio G, Palazón A, Sancho-Bru P, Elguezabal N, Fraga MF, Ávila MA, Bataller R, Marín JJG, Martín F, Martínez-Chantar ML. Goikoetxea-Usandizaga N, et al. Among authors: bravo m. Hepatology. 2023 Sep 1;78(3):878-895. doi: 10.1097/HEP.0000000000000303. Epub 2023 Feb 9. Hepatology. 2023. PMID: 36745935 Free PMC article.
Simvastatin-loaded polymeric micelles are more effective and less toxic than conventional statins in a pre-clinical model of advanced chronic liver disease.
Hide D, Gil M, Andrade F, Rafael D, Raurell I, Bravo M, Barberá A, Gracia-Sancho J, Vargas V, Augustin S, Genescà J, Schwartz S Jr, Martell M. Hide D, et al. Among authors: bravo m. Nanomedicine. 2020 Oct;29:102267. doi: 10.1016/j.nano.2020.102267. Epub 2020 Jul 15. Nanomedicine. 2020. PMID: 32681987
1,120 results