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Tissue-Specific Oncogenic Activity of KRASA146T.
Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM. Poulin EJ, et al. Among authors: braun bs. Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5. Cancer Discov. 2019. PMID: 30952657 Free PMC article.
Oncogenic Kras initiates leukemia in hematopoietic stem cells.
Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS. Sabnis AJ, et al. Among authors: braun bs. PLoS Biol. 2009 Mar 17;7(3):e59. doi: 10.1371/journal.pbio.1000059. PLoS Biol. 2009. PMID: 19296721 Free PMC article.
Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras.
Akutagawa J, Huang TQ, Epstein I, Chang T, Quirindongo-Crespo M, Cottonham CL, Dail M, Slusher BS, Friedman LS, Sampath D, Braun BS. Akutagawa J, et al. Among authors: braun bs. Leukemia. 2016 Jun;30(6):1335-43. doi: 10.1038/leu.2016.14. Epub 2016 Feb 12. Leukemia. 2016. PMID: 26965285 Free PMC article.
A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies.
Maertens O, McCurrach ME, Braun BS, De Raedt T, Epstein I, Huang TQ, Lauchle JO, Lee H, Wu J, Cripe TP, Clapp DW, Ratner N, Shannon K, Cichowski K. Maertens O, et al. Among authors: braun bs. Cancer Res. 2017 Nov 1;77(21):5706-5711. doi: 10.1158/0008-5472.CAN-17-1789. Epub 2017 Oct 9. Cancer Res. 2017. PMID: 28993414 Free PMC article. Review.
KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.
Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. Wong JC, et al. Among authors: braun bs. JCI Insight. 2020 Nov 5;5(21):e140495. doi: 10.1172/jci.insight.140495. JCI Insight. 2020. PMID: 32990679 Free PMC article.
Targeting Ras in myeloid leukemias.
Braun BS, Shannon K. Braun BS, et al. Clin Cancer Res. 2008 Apr 15;14(8):2249-52. doi: 10.1158/1078-0432.CCR-07-1005. Clin Cancer Res. 2008. PMID: 18413813 Review.
47 results