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Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.
O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d'Andrea AL, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, Palmer KE. O'Keefe BR, et al. Among authors: bratcher b. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6099-104. doi: 10.1073/pnas.0901506106. Epub 2009 Mar 30. Proc Natl Acad Sci U S A. 2009. PMID: 19332801 Free PMC article.
Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques.
Olinger GG Jr, Pettitt J, Kim D, Working C, Bohorov O, Bratcher B, Hiatt E, Hume SD, Johnson AK, Morton J, Pauly M, Whaley KJ, Lear CM, Biggins JE, Scully C, Hensley L, Zeitlin L. Olinger GG Jr, et al. Among authors: bratcher b. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18030-5. doi: 10.1073/pnas.1213709109. Epub 2012 Oct 15. Proc Natl Acad Sci U S A. 2012. PMID: 23071322 Free PMC article.
Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression systems.
Pogue GP, Vojdani F, Palmer KE, Hiatt E, Hume S, Phelps J, Long L, Bohorova N, Kim D, Pauly M, Velasco J, Whaley K, Zeitlin L, Garger SJ, White E, Bai Y, Haydon H, Bratcher B. Pogue GP, et al. Among authors: bratcher b. Plant Biotechnol J. 2010 Jun;8(5):638-54. doi: 10.1111/j.1467-7652.2009.00495.x. Plant Biotechnol J. 2010. PMID: 20514694 Free article. Review.
Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail.
Pettitt J, Zeitlin L, Kim DH, Working C, Johnson JC, Bohorov O, Bratcher B, Hiatt E, Hume SD, Johnson AK, Morton J, Pauly MH, Whaley KJ, Ingram MF, Zovanyi A, Heinrich M, Piper A, Zelko J, Olinger GG. Pettitt J, et al. Among authors: bratcher b. Sci Transl Med. 2013 Aug 21;5(199):199ra113. doi: 10.1126/scitranslmed.3006608. Sci Transl Med. 2013. PMID: 23966302
CoV-RBD121-NP Vaccine Candidate Protects against Symptomatic Disease following SARS-CoV-2 Challenge in K18-hACE2 Mice and Induces Protective Responses That Prevent COVID-19-Associated Immunopathology.
DeMarco JK, Royal JM, Severson WE, Gabbard JD, Hume S, Morton J, Swope K, Simpson CA, Shepherd JW, Bratcher B, Palmer KE, Pogue GP. DeMarco JK, et al. Among authors: bratcher b. Vaccines (Basel). 2021 Nov 17;9(11):1346. doi: 10.3390/vaccines9111346. Vaccines (Basel). 2021. PMID: 34835277 Free PMC article.
Reproducibility and flexibility of monoclonal antibody production with Nicotiana benthamiana.
Swope K, Morton J, Pogue GP, Burden L, Partain N, Hume S, Shepherd J, Simpson CA, Brennan MB, Furman TC, Kingrey-Gebe S, Martinez T, McDonough J, Pauly MH, Whaley KJ, Zeitlin L, Bratcher B, Haydon H. Swope K, et al. Among authors: bratcher b. MAbs. 2022 Jan-Dec;14(1):2013594. doi: 10.1080/19420862.2021.2013594. MAbs. 2022. PMID: 35000569 Free PMC article.
Development of a SARS-CoV-2 Vaccine Candidate Using Plant-Based Manufacturing and a Tobacco Mosaic Virus-like Nano-Particle.
Royal JM, Simpson CA, McCormick AA, Phillips A, Hume S, Morton J, Shepherd J, Oh Y, Swope K, DeBeauchamp JL, Webby RJ, Cross RW, Borisevich V, Geisbert TW, Demarco JK, Bratcher B, Haydon H, Pogue GP. Royal JM, et al. Among authors: bratcher b. Vaccines (Basel). 2021 Nov 17;9(11):1347. doi: 10.3390/vaccines9111347. Vaccines (Basel). 2021. PMID: 34835278 Free PMC article.
Hexavalent sperm-binding IgG antibody released from vaginal film for development of potent on-demand nonhormonal female contraception.
Shrestha B, Vincent K, Schaefer A, Zhu Y, Vargas G, Motamedi M, Swope K, Morton J, Simpson C, Pham H, Brennan MB, Pauly MH, Zeitlin L, Bratcher B, Whaley KJ, Moench TR, Lai SK. Shrestha B, et al. Among authors: bratcher b. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2107832118. doi: 10.1073/pnas.2107832118. Proc Natl Acad Sci U S A. 2021. PMID: 34815336 Free PMC article.
13 results